A role of uroleuconaphins, polyketide red pigments in aphid, as a chemopreventor in the host defense system against infection with entomopathogenic fungi
| Autor: | Makoto Inai, Hiroto Kaku, Mitsuaki Shimazu, Maki Aibe, Tetsuto Tsunoda, Mitsuyo Horikawa |
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| Rok vydání: | 2018 |
| Předmět: |
Antifungal Agents
media_common.quotation_subject Insect 010402 general chemistry 01 natural sciences Polyketide Ascomycota Glucosides Drug Discovery Botany Animals media_common Pharmacology Aphid Entomophthoromycota biology 010405 organic chemistry Host (biology) Fungi biology.organism_classification 0104 chemical sciences Mycoses Aphids Polyketides Hypocreales Entomophthorales Sugars Cordycipitaceae |
| Zdroj: | The Journal of antibiotics. 71(12) |
| ISSN: | 1881-1469 |
| Popis: | Four red polyketide pigments, uroleuconaphins A1 (1) and B1 (2) and their glucosides 3 and 4, were isolated from the red goldenrod aphid Uroleucon nigrotuberculatum. Although these red pigments exist only as glucosides 3 and 4 in the intact insect body, 3 and 4 convert instantly to aglycones 1 and 2 at death. Pigments 1 and 2 inhibited the growth of Lecanicillium sp. (Ascomycota: Cordycipitaceae) and 1, 2, and 3 were active against Conidiobolus obscurus (Entomophthoromycota; Entomophthorales); these fungal species are pathogenic. We therefore regard aphid pigments 1–4 as chemopreventive agents that aid in the resistance of infection by entomopathogenic fungi at the level of the individual aphid and/or at the species level. |
| Databáze: | OpenAIRE |
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