Five-year Results of a Randomised Clinical Trial of Endovenous Laser Ablation of the Great Saphenous Vein with and without Ligation of the Saphenofemoral Junction
| Autor: | B.C.V.M. Disselhoff, D.J. der Kinderen, Frans L. Moll, J.C. Kelder |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors law.invention Varicose Veins Saphenofemoral ligation Young Adult Randomized controlled trial law Varicose veins Humans Medicine Saphenous Vein Recurrent varicose veins Ligation Aged Retrospective Studies Medicine(all) Ultrasonography Doppler Duplex Groin business.industry Endovascular Procedures Great saphenous vein Retrospective cohort study Femoral Vein Middle Aged Vascular surgery Surgery Endovenous laser ablation Clinical trial Treatment Outcome medicine.anatomical_structure cardiovascular system Female Laser Therapy medicine.symptom Cardiology and Cardiovascular Medicine business Follow-Up Studies |
| Zdroj: | European Journal of Vascular and Endovascular Surgery. 41:685-690 |
| ISSN: | 1078-5884 |
| DOI: | 10.1016/j.ejvs.2010.12.014 |
| Popis: | Objective: To evaluate whether ligation of the saphenofemoral junction (SFL) improves the results of endovenous laser ablation (EVLA) of the great saphenous vein (GSV) in a 5-year randomised clinical trial (RCT). Methods: Forty-three symptomatic patients (86 limbs) with bilateral incompetent GSVs were randomised so that one limb underwent EVLA without SFL and the other limb underwent EVLA with SFL. Eleven patients were lost to follow-up and two patients died, leaving 30 patients (60 limbs) for analysis. Duplex-confirmed groin varicose vein recurrence and venous clinical severity score (VCSS) were investigated at 6, 12, 24 and 60 months after treatment. Results: Five-yearlifetableanalysisshowedfreedomfromgroinvaricoseveinrecurrencein79%of limbs(95%confidenceinterval(CI);67e92%)intheEVLAwithoutSFLgroupandin65%oflimbs(95%; CI; 51e82) in the EVLA with SFL group (P Z 0.36). Groin varicose vein recurrence was due to neo- vascularisation (0%), re-canalisation (9%) and incompetent tributaries in 14% in the EVLA without SFL group, and to neo-vascularisation (33%), re-canalisation (0%) and incompetent tributaries (0%)intheEVLAwithSFLgroup.TheVCSSimprovedsignificantlyandwascomparableinbothgroups. Conclusion: The rate of varicose vein recurrence was similar in both study groups. There was less neo-vascularisation in the EVLA without SFL group, but more incompetent tributaries and early re-canalisation at 5-year follow-up than in the EVLA with SFL group. Registration number: ISRCTN60300873 (http://www.clinical-trials.com). a 2011 Published by Elsevier Ltd on behalf of European Society for Vascular Surgery. |
| Databáze: | OpenAIRE |
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