Determination of the source(s) of androgen overproduction in hirsutism associated with polycystic ovary syndrome by simultaneous adrenal and ovarian venous catheterization. Comparison with the dexamethasone suppression test
| Autor: | Sergio S. Lima, Carlos Eduardo Czeresnia, Helena Okada, Setsuko S. Achando, Jayme Goldman, Bernardo Léo Wajchenberg, Sérgio Peixoto |
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| Rok vydání: | 1986 |
| Předmět: |
Adult
medicine.medical_specialty Hirsutism Adolescent medicine.drug_class Endocrinology Diabetes and Metabolism Clinical Biochemistry Dehydroepiandrosterone Ovary Biochemistry Dexamethasone Catheterization chemistry.chemical_compound Endocrinology Dehydroepiandrosterone sulfate Internal medicine Adrenal Glands medicine Humans Testosterone hirsutism business.industry Biochemistry (medical) Androstenedione medicine.disease Androgen Polycystic ovary medicine.anatomical_structure chemistry Dexamethasone suppression test Androgens Female business Polycystic Ovary Syndrome |
| Zdroj: | The Journal of clinical endocrinology and metabolism. 63(5) |
| ISSN: | 0021-972X |
| Popis: | To determine the source(s) of the excessive androgen production in patients with the polycystic ovary syndrome (PCOS), 12 hirsute women with PCOS underwent selective left adrenal and left ovarian venous catheterization. Blood samples were collected simultaneously for determination of cortisol, 17-hydroxy-progesterone, androstenedione (delta), testosterone (T), dehydroepiandrosterone, and dehydroepiandrosterone sulfate. The relative contributions of adrenal secretion rates of T and delta in each patient were estimated by relating their adrenal gradients to those of cortisol. From such calculations we found that in all patients the major source of androgens was the ovary (direct ovarian secretion and/or ovarian secretion of prehormones which then were converted to androgen in the peripheral circulation). After catheterization, 11 of the 12 patients underwent a 5-day dexamethasone suppression test (2 mg/day). In 7 patients studied, plasma delta and/or T levels decreased significantly. Our results indicate that in hirsutism associated with the PCOS, the predominant source of androgens is the ovaries and that glucocorticoid suppression cannot assign adrenal origin as the site of excessive androgens. |
| Databáze: | OpenAIRE |
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