Amelioration of intrathymic T cell development and peripheral T cell reactivities in autoimmune mice undergoing therapy with a novel immunomodulator
| Autor: | Anna-Lena Spetz-Hagberg, Torbjörn Stålhandske, Eva-Lotta Larsson-Sciard, Tom J. Goldschmidt |
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| Rok vydání: | 1990 |
| Předmět: |
T cell
T-Lymphocytes Immunology Cell Count urologic and male genital diseases medicine.disease_cause Lymphocyte Activation Autoimmunity Autoimmune Diseases Pathogenesis Mice Adjuvants Immunologic immune system diseases Aldesleukin In vivo T-Lymphocyte Subsets medicine Immunology and Allergy Animals skin and connective tissue diseases Autoimmune disease business.industry Cell Differentiation General Medicine T lymphocyte medicine.disease Mice Mutant Strains Lymphatic system medicine.anatomical_structure Phenotype Hydroxyquinolines business |
| Zdroj: | International immunology. 2(7) |
| ISSN: | 0953-8178 |
| Popis: | MRL lpr/lpr mice develop a generalized autoimmune disease associated with a massive accumulation in the peripheral lymphoid organs of abnormal, phenotypically immature T cells. Both the lymphoadenopathy and the autoimmunity are thymus-dependent and likely to arise from an aberrant pathway of intrathymic differentiation. We here present the marked beneficial effects acquired in MRL lpr/lpr mice after in vivo administration of a novel immunomodulator called linomide. The highly altered pattern of thymic subpopulations in MRL lpr/lpr mice is normalized after linomide-treatment. Concomitantly, the peripheral T cell compartment, which in MRL lpr/lpr is highly deficient in producing and responding to IL-2, gains substantial functional reactivities. We propose that linomide acts by correcting the abnormal T cell development in autoimmune MRL lpr/lpr mice. This new immunomodulator may be a useful tool for providing insight into both the pathogenesis of autoimmune disorders and intrathymic differentiation. |
| Databáze: | OpenAIRE |
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