Cas Adaptor Proteins Organize the Retinal Ganglion Cell Layer Downstream of Integrin Signaling
| Autor: | Sachiko Seo, Alex L. Kolodkin, Mineo Kurokawa, Martin M. Riccomagno, Colleen M. Brady, Lu O. Sun, Konstantina Alexandropoulos |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Retinal Ganglion Cells
Neuroscience(all) 1.1 Normal biological development and functioning Integrin Mice Transgenic Biology Eye Retinal ganglion Article Retina Transgenic Mice chemistry.chemical_compound Underpinning research Laminin medicine Animals Psychology Eye Disease and Disorders of Vision Neurons Neurology & Neurosurgery Integrin beta1 General Neuroscience Neurosciences Signal transducing adaptor protein Retinal eye diseases Cell biology Crk-Associated Substrate Protein medicine.anatomical_structure chemistry Retinal ganglion cell biology.protein Cognitive Sciences sense organs Signal transduction Signal Transduction |
| Zdroj: | Neuron, vol 81, iss 4 |
| ISSN: | 0896-6273 |
| DOI: | 10.1016/j.neuron.2014.01.036 |
| Popis: | Stratification of retinal neuronal cell bodies and lamination of their processes provide a scaffold upon which neural circuits can be built. However, the molecular mechanisms that direct retinal ganglion cells (RGCs) to resolve into a single-cell retinal ganglion cell layer (GCL) are not well understood. The extracellular matrix protein laminin conveys spatial information that instructs the migration, process outgrowth, and reorganization of GCL cells. Here, we show that the β1-Integrin laminin receptor is required for RGC positioning and reorganization into a single-cell GCL layer. β1-Integrin signaling within migrating GCL cells requires Cas signaling-adaptor proteins, and in the absence of β1-Integrin or Cas function retinal neurons form ectopic cell clusters beyond the inner limiting membrane (ILM), phenocopying laminin mutants. These data reveal a novel and essential role for Cas adaptor proteins in β1-Integrin-mediated signaling events critical for the formation of the single-cell GCL in the mammalian retina. |
| Databáze: | OpenAIRE |
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