Ozone inhalation in rats: effects on alkaline phosphatase and lactic dehydrogenase isoenzymes in lavage and plasma
| Autor: | R. C. Miles, H. L. Moon, J. P. Nachtman |
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| Rok vydání: | 1988 |
| Předmět: |
Male
Neutrophils Health Toxicology and Mutagenesis Lymphocyte Phosphatase Biology Toxicology chemistry.chemical_compound Leukocyte Count Ozone Lactate dehydrogenase Blood plasma medicine Animals Therapeutic Irrigation L-Lactate Dehydrogenase Acid phosphatase General Medicine Alkaline Phosphatase Pollution Molecular biology Rats Inbred F344 Rats Isoenzymes medicine.anatomical_structure Biochemistry chemistry Toxicity biology.protein Alkaline phosphatase Creatine kinase Oxidation-Reduction |
| Zdroj: | Bulletin of environmental contamination and toxicology. 41(4) |
| ISSN: | 0007-4861 |
| Popis: | Ozone is found in urban and rural atmospheres and is produced from a variety of natural and man-made sources. Animal studies conducted at typical ambient levels result in reproducible morphological, biochemical and functional effects. Ozone damages type I epithelial cells, induces proliferation of type II cells and produces inflammation of the terminal bronchiolar-alveolar duct region. Ozone increases lung oxygen utilization and increases glutathione metabolism. Ozone increases airway resistance. The authors measured lactic dehydrogenase (LD) isoenzymes to ascertain the tissue giving rise to the increased LD activity in lavage. They also assayed acid phosphatase, alkaline phosphatase, creatine kinase activities, and protein levels since these parameters were increased in rat lung lavage after particulate exposure. They determined white cell differential and red cell morphology parameters because previous investigators reported that ozone increased neutrophil/lymphocyte ratio. |
| Databáze: | OpenAIRE |
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