Cancer Stem Cell Metabolism
| Autor: | Arvin M. Gouw, Fidelia B. Alvina, Anne Le |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0303 health sciences
Lung Neoplasms Cellular differentiation Myeloid leukemia Cancer Cell Differentiation Biology medicine.disease_cause medicine.disease Leukemia Myeloid Acute 03 medical and health sciences Cell Transformation Neoplastic 0302 clinical medicine Cancer stem cell 030220 oncology & carcinogenesis Cancer cell Neoplastic Stem Cells Cancer research medicine Humans Progenitor cell Stem cell Carcinogenesis Research Article 030304 developmental biology |
| Zdroj: | The Heterogeneity of Cancer Metabolism ISBN: 9783030657673 Adv Exp Med Biol |
| DOI: | 10.1007/978-3-030-65768-0_12 |
| Popis: | Cancer stem cells (CSCs), also known as tumorinitiating cells (TICs), are a group of cells found within cancer cells. Like normal stem cells, CSCs can proliferate, engage in self-renewal, and are often implicated in the recurrence of tumors after therapy [1, 2]. The existence of CSCs in various types of cancer has been proven, such as in acute myeloid leukemia (AML) [3], breast [4], pancreatic [5], and lung cancers [6], to name a few. There are two theories regarding the origin of CSCs. First, CSCs may have arisen from normal stem/progenitor cells that experienced changes in their environment or genetic mutations. On the other hand, CSCs may also have originated from differentiated cells that underwent genetic and/or heterotypic modifications [7]. Either way, CSCs reprogram their metabolism in order to support tumorigenesis. |
| Databáze: | OpenAIRE |
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