The Effect of Graft-Bed Irradiation on the Healing of Rat Skin Grafts
| Autor: | Qi Wang, K. E. Carr, Glenn R. Dickson |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Male
Pathology medicine.medical_specialty Time Factors electron-radiation Dermatology Fibrinogen Biochemistry Fibrin Rats Sprague-Dawley Electron radiation medicine Animals Irradiation Molecular Biology Wound Healing quantitation integumentary system biology Radiotherapy Chemistry auto-transplantation Granulation tissue Skin Transplantation Cell Biology Rats Fibronectin surgical procedures operative medicine.anatomical_structure microscopy biology.protein Immunohistochemistry Full thickness medicine.drug |
| Zdroj: | Journal of Investigative Dermatology. 106(5):1053-1057 |
| ISSN: | 0022-202X |
| DOI: | 10.1111/1523-1747.ep12338649 |
| Popis: | This study explores the possible side effects on healing skin grafts of irradiation, commonly used intra-operatively following surgical tumor removal. The experimental model involved the delivery of a single 10-Gy dose of electron radiation to the recipient bed of a skin wound, followed by attachment of a full thickness rat skin autograft. Skin graft repair was assessed by light microscopy, immunohistochemistry, and transmission electron microscopy over a 3-week period for grafted and grafted-irradiated groups. Graft-bed irradiation reduced fibrinogen, fibrin, and fibronectin deposition in the wound. It also produced brief changes in the extent of both re-epithelialization and granulation tissue formation, and reduced the diameter of collagen fibrils in the granulation tissue. Despite these changes, the results suggest that graft-bed irradiation only delays the healing process, producing no serious clinical complications at the time points studied. |
| Databáze: | OpenAIRE |
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