Synergistic interaction between midazolam and propofol
| Autor: | P.M.C. Wright, A. C. McKAY, Christopher Patterson, R.S.J. Clarke, S. McCLUNE |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adult
genetic structures Adolescent Consciousness medicine.drug_class Midazolam Blood Pressure Pharmacology Hypnotic Random Allocation Heart Rate medicine Humans Propofol ED50 Dose-Response Relationship Drug business.industry Surrogate endpoint Drug Synergism Middle Aged Confidence interval Anesthesiology and Pain Medicine Isoflurane Anesthesia Reflex Anesthesia Intravenous Female business medicine.drug |
| Zdroj: | British journal of anaesthesia. 69(3) |
| ISSN: | 0007-0912 |
| Popis: | We gave either midazolam or propofol for induction of anaesthesia to 140 ASA I or II female patients (18–60 yr). ED50, values were obtained by probit analysis for three clinical end-points: loss of response to command; loss of eyelash reflex; failure to respond to application of an anaesthetic face mask delivering 1 % isoflurane. Propofol ED50 values (95% confidence intervals) were 1.25 (0.99–1.48) mgkg−1, 1.61 (1.29–1.94) mg kg−1 and1.51 (1.20–1.82) mg kg−1, respectively. ED50 values for midazolam were 0.26 (0.20–0.37) mg kg−1, 0.29 (0.23–0.47) mgkg−1 and 0.25 (0.20–0.32) mg kg−1, respectively. An additional 92 similar patients received one of nine dose combinations of midazolam and propofol for induction of anaesthesia, propofol being administered 2 min after midazolam. Success of induction was based on the clinical end-point of loss of response to command. Administration of 25% of the ED50 of midazolam followed by 50% of the ED50 of propofol resulted in loss of response to command in 50 % of patients, while 50 % of the ED50 of midazolam, followed by 25% of the ED50 of propofol had the same effect. A probit regression model specifying a synergistic interaction between midazolam and propofol fitted the data significantly better than a model specifying no interaction. |
| Databáze: | OpenAIRE |
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