Topical treatment of mild to moderate plaque psoriasis with 0.3% tacrolimus gel and 0.5% tacrolimus cream: the effect on SUM score, epidermal proliferation, keratinization, T-cell subsets and HLA-DR expression

Autor: E.M.G.J. de Jong, W.H.P.M. Vissers, P.E.J. van Erp, I. M. J. J. Van Vlijmen, P.C.M. van de Kerkhof
Rok vydání: 2008
Předmět:
Keratinocytes
medicine.medical_specialty
medicine.medical_treatment
T cell
chemical and pharmacologic phenomena
Dermatology
Pharmacology
Auto-immunity
transplantation and immunotherapy [N4i 4]
Severity of Illness Index
Tacrolimus
chemistry.chemical_compound
Calcitriol
T-Lymphocyte Subsets
Psoriasis
Skin Physiological Phenomena
medicine
Humans
Calcipotriol
Chronic inflammation and autoimmunity [UMCN 4.2]
Chemotherapy
Protein synthesis inhibitor
integumentary system
business.industry
Drug Administration Routes
HLA-DR Antigens
medicine.disease
Immunohistochemistry
Calcineurin
Pathogenesis and modulation of inflammation [N4i 1]
medicine.anatomical_structure
Treatment Outcome
surgical procedures
operative
chemistry
Dermatologic Agents
Keratinocyte
business
Gels
Immunosuppressive Agents
Immunity
infection and tissue repair [NCMLS 1]
Zdroj: British Journal of Dermatology, 158, 705-12
British Journal of Dermatology, 158, 4, pp. 705-12
ISSN: 0007-0963
Popis: Contains fulltext : 70573.pdf (Publisher’s version ) (Closed access) BACKGROUND: Tacrolimus gel 0.3% and tacrolimus cream 0.5% were studied and compared with calcipotriol ointment 0.005%, as topical treatment for mild to moderate plaque psoriasis. Tacrolimus is able to inhibit several cellular processes thought to be important in the pathogenesis of psoriasis, e.g. the transcription of proinflammatory cytokines, keratinocyte hyperproliferation and the expression of HLA-DR in lesional psoriatic skin. METHOD: In the present study we investigated the effects of preparations of tacrolimus and calcipotriol ointment on SUM score, hyperproliferation (Ki67-positive keratinocytes), keratinization (percentage keratin 10 (K10)-positive epidermal surface), T-cell subsets (CD4, CD8, CD45RO, CD45RA, CD2, CD25), cells expressing natural killer receptors and HLA-DR expression. The following three topical treatments were studied in chronic plaque psoriasis over a 12-week treatment period: calcipotriol ointment 0.005% twice daily, tacrolimus gel 0.3% twice daily and tacrolimus cream 0.5% twice daily. RESULTS: The mean reductions in SUM score between day 0 and week 12 for calcipotriol ointment, tacrolimus gel and cream were significant. Calcipotriol ointment, and tacrolimus gel and cream had a comparable effect on epidermal proliferation (Ki67-positive cells), but calcipotriol is significantly more effective in normalizing differentiation (K10-positive epidermal surface). Calcipotriol and tacrolimus gel both reduced several lesional T-cell subsets significantly, whereas the effect induced by tacrolimus cream was modest. CONCLUSIONS: Calcipotriol and tacrolimus gel are comparable in reducing the SUM score, the number of Ki67-positive cells and T-cell subsets and HLA-DR expression, although calcipotriol induces a more substantial improvement of keratinization.
Databáze: OpenAIRE
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