ALDH2, ADCY3 and BCMO1 polymorphisms and lifestyle-induced traits are jointly associated with CAD risk in Chinese Han people
Autor: | Xiao-yu Yin, Jin-Mei Li, Cheng-yin Ye, Jia-rui Xin, Li Wang, Tian-Yu Zhao, Shu-li Guo, Zheng Li, Lei Yang |
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Rok vydání: | 2021 |
Předmět: |
Oncology
Male medicine.medical_specialty China Single-nucleotide polymorphism CAD Coronary Artery Disease Biology Coronary artery disease Asian People Risk Factors Internal medicine Genotype Genetics medicine Odds Ratio Humans Genetic Predisposition to Disease Life Style ALDH2 Aged beta-Carotene 15 15'-Monooxygenase Polymorphism Genetic Aldehyde Dehydrogenase Mitochondrial Area under the curve General Medicine Odds ratio Middle Aged ADCY3 medicine.disease Area Under Curve Case-Control Studies Hypertension Female Waist Circumference Algorithms Adenylyl Cyclases |
Zdroj: | Gene. 807 |
ISSN: | 1879-0038 |
Popis: | To investigate associations of genetic and environmental factors with coronary artery disease (CAD), we collected medical reports, lifestyle details, and blood samples of 2113 individuals, and then used the polymerase chain reaction (PCR)-ligase detection reaction (LDR) to genotype the targeted 102 SNPs.We adopted elastic net algorithm to build an association model that considered simultaneously genetic and lifestyle/clinical factors associated with CAD in Chinese Han population.In this study, we developed an all covariates-based model to explain the risk of CAD, which incorporated 8 lifestyle/clinical factors and a gene-score variable calculated from 3 significant SNPs (rs671, rs6751537 and rs11641677), attaining an area under the curve (AUC) value of 0.71. It was found that, in terms of genetic variants, the AA genotype of rs671 in the additive (adjusted odds ratio (OR) = 2.51, p = 0.008) and recessive (adjusted OR = 2.12, p = 0.021) models, the GG genotype of rs6751537 in the additive (adjusted OR = 3.36, p = 0.001) and recessive (adjusted OR = 3.47, p = 0.001) models were associated with increased risk of CAD, while GG genotype of rs11641677 in additive model (adjusted OR = 0.39, p = 0.044) was associated with decreased risk of CAD. In terms of lifestyle/clinical factors, the history of hypertension (unadjusted OR = 2.37, p 0.001) and dyslipidemia (unadjusted OR = 1.82, p = 0.007), age (unadjusted OR = 1.07, p 0.001) and waist circumference (unadjusted OR = 1.02, p = 0.05) would significantly increase the risk of CAD, while height (unadjusted OR = 0.97, p = 0.006) and regular intake of chicken (unadjusted OR = 0.78, p = 0.008) reduced the risk of CAD. A significantinteraction was foundbetween rs671 and dyslipidemia (the relative excess risk due to interaction (RERI) = 3.36, p = 0.05).In this study, we constructed an association model and identified a set of SNPs and lifestyle/clinical risk factors of CAD in Chinese Han population. By considering both genetic and non-genetic risk factors, the built model may provide implications for CAD pathogenesis and clues for screening tool development in Chinese Han population. |
Databáze: | OpenAIRE |
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