Secondary hyperparathyroidism: detection with I-123-Tc-99m-Sestamibi subtraction scintigraphy versus US
| Autor: | Hatem Boulahdour, P Prieur, P. Galle, V. Menoyo-Calonge, Didier Mellière, A Janin, Pablo Ureña, C Jeanguillaume, D Chiappini-Briffa, Elif Hindié, M Pétrover |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
Male Technetium Tc 99m Sestamibi medicine.medical_specialty Scintigraphy Sensitivity and Specificity Technetium (99mTc) sestamibi Subtotal Parathyroidectomy Iodine Radioisotopes Parathyroid Glands medicine Humans Radiology Nuclear Medicine and imaging Radionuclide Imaging Aged Ultrasonography Aged 80 and over Hyperparathyroidism medicine.diagnostic_test business.industry Subtraction Middle Aged medicine.disease Subtraction Technique Female Hyperparathyroidism Secondary Secondary hyperparathyroidism Radiology business Nuclear medicine medicine.drug |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1527-1315 0033-8419 |
| DOI: | 10.1148/radiology.207.1.9580138 |
| Popis: | To compare iodine-123-technetium-99m-sestamibi subtraction scintigraphy with ultrasonography (US) for detection of parathyroid abnormalities in uremic patients with secondary hyperparathyroidism.Fourteen adult uremic patients with severe secondary hyperparathyroidism underwent subtraction scintigraphy before total or subtotal parathyroidectomy. Subtraction scintigrams were acquired with a double-energy-window technique. US was performed with high-frequency transducers and standard methods.1-123-Tc-99m-sestamibi subtraction scintigraphy correctly demonstrated 41 of 50 surgically confirmed enlarged parathyroids; US demonstrated 27. Sensitivity for detection of hyperplastic glands was 82% for scintigraphy and 54% for US. Scintigrams were correct in seven patients, and US scans were correct in five. Scintigraphy demonstrated all four enlarged parathyroids in six of 12 patients who were to undergo first surgery, whereas US demonstrated all four enlarged glands in three of the 12 patients. Gland weight was correlated with likelihood of detection with either method. Glands undetected at scintigraphy were significantly (P.01) smaller (mean weight, 257 mg) than those undetected at US (mean weight, 467 mg).I-123-Tc-99m-sestamibi subtraction scintigraphy is efficient for detection of enlarged parathyroid glands in uremic patients with secondary hyperparathyroidism and is more sensitive than US. |
| Databáze: | OpenAIRE |
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