The impact of maternal neglect on genetic hyperactivity
| Autor: | Justin S. Rhodes, Petra Majdak, Elizabeth L. Grogan, Anastassia Sorokina, Stephen Tse, Joseph V. Gogola |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Offspring Weaning Environment Hyperkinesis Selective breeding Article Developmental psychology 03 medical and health sciences Behavioral Neuroscience Mice 0302 clinical medicine Transgenerational epigenetics Postnatal stress Animals Maternal Behavior Maternal neglect Behavior Animal Cognition Early life 030104 developmental biology Phenotype Animals Newborn Female Psychology 030217 neurology & neurosurgery |
| Zdroj: | Behavioural brain research. 313 |
| ISSN: | 1872-7549 |
| Popis: | Early environmental conditions are increasingly appreciated as critical in shaping behavior and cognition. Evidence suggests that stressful rearing environments can have an enduring impact on behaviors in adulthood, but few studies have explored the possibility that rearing environment could exacerbate genetic hyperactivity disorders. Uncovering a strong environmental influence on the transmission of hyperactivity could provide novel avenues for translational research. Recently we developed a selectively bred High-Active line of mice to model ADHD, providing a unique resource to address the question of environmental transmission. The High-Active line demonstrates transgenerational hyperactivity, but the influence of the postnatal environment (i.e. maternal care provided by dams) on hyperactivity had not been systemically quantified. This study employed a cross-fostering method to simultaneously address 1) whether High-Active and Control pups are provided with similar levels of care in the early environment, and 2) whether any differences in rearing environment influence hyperactive behavior. High-Active dams demonstrated impairment in all measures of maternal competence relative to Controls, which reduced survival rates and significantly reduced the body mass of offspring in early life and at weaning. While the deteriorated postnatal environment provided by High-Active dams was ultimately sufficient to depress Control activity, the hyperactivity of High-Active offspring remained unaffected by fostering condition. These data not only confirm the power of genetics to influence hyperactivity across generations, but also provide evidence that early rearing environments may not have a significant impact on the extreme end of hyperactive phenotypes. |
| Databáze: | OpenAIRE |
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