Hepatitis C virus genotypes in Australia
| Autor: | Bowden Ds, Stephen Locarnini, Moaven Ld, R. McCaw |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Serotype
Adult Male Genotype Hepatitis C virus Hepacivirus Biology medicine.disease_cause Polymerase Chain Reaction law.invention Gene Frequency law Virology medicine Humans Serotyping Substance Abuse Intravenous Genotyping Allele frequency Polymerase chain reaction Aged Hepatology Incidence (epidemiology) Age Factors Australia Hepatitis C Middle Aged medicine.disease Infectious Diseases Female |
| Zdroj: | Journal of viral hepatitis. 4(5) |
| ISSN: | 1352-0504 |
| Popis: | The relative distribution of Australian hepatitis C virus (HCV) genotypes was determined for 500 isolates. Genotyping was performed using a commercial reverse phase hybridization assay after amplification of the 5' untranslated region of HCV by the polymerase chain reaction. Australian isolates comprised, predominantly, genotype 1 (55%) and genotype 3 (38%) with genotype 2 accounting for only 7%. Genotype 3a was the most common subtype. When the major risk groups of injecting drug users or transfusion-acquired hepatitis C were compared, there was a significantly higher incidence of genotype 1b in the transfusion-acquired group (P < 0.03). When the age of the patients was analysed, genotype 3a was more prevalent in the 21-40-year age group than the 41-60-year age group (P < 0.05). There was no significant difference in genotype distribution between males and females. HCV genotypes 1, 2 and 3 are most often found in developed countries but the relatively high prevalence of genotype 3a in Australia is unusual. |
| Databáze: | OpenAIRE |
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