Accelerated biological ageing in HIV-infected individuals in South Africa
| Autor: | Linda-Gail Bekker, Dagmara McGuinness, Paul G. Shiels, Helen A. Weiss, Theresa Christ, Stephen D. Lawn, Sophia Pathai, Karen Barclay, Jennifer Port, Liane M. McGlynn, Clare Gilbert, Robin Wood |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Aging Immunology Physiology HIV Infections Biology South Africa CDKN2A 03 medical and health sciences 0302 clinical medicine Hiv infected Leukocytes Humans Immunology and Allergy 030212 general & internal medicine Prospective cohort study Cyclin-Dependent Kinase Inhibitor p16 030304 developmental biology 0303 health sciences Case-control study HIV virus diseases Middle Aged Telomere Viral Load Clinical Science telomeres Antiretroviral therapy CD4 Lymphocyte Count 3. Good health accelerated ageing Infectious Diseases Anti-Retroviral Agents Ageing Case-Control Studies Africa Biomarker (medicine) Female Viral load biomarkers of ageing |
| Zdroj: | AIDS (London, England) |
| ISSN: | 0269-9370 |
| Popis: | Objectives: Little is known about the impact of HIV infection on biological ageing in sub-Saharan Africa. The study aimed to assess biological ageing in South African HIV-infected adults and HIV-seronegative individuals using two validated biomarkers, telomere length and CDKN2A expression (a mediator of cellular senescence). Design: A case–control study. Methods: Two hundred and thirty-six HIV-infected adults aged at least 30 years and 250 age and sex frequency matched HIV-seronegative individuals were recruited from clinics in township communities in Cape Town. Biological ageing was evaluated by measurement of telomere length and CDKN2A expression in peripheral blood leukocytes. Results: The median ages of the HIV-infected and HIV-seronegative participants were 39 and 40 years, respectively. Among HIV-infected participants, 87.1% were receiving antiretroviral therapy (ART), their median CD4+ cell count was 468 cells/μl and 84.3% had undetectable viral load. Both biomarkers were validated against chronological age in HIV-seronegative individuals. Telomere length was significantly shorter in HIV-infected individuals than in HIV-seronegative individuals (mean relative T/S ratio ±SE:0.91 ± 0.007 vs. 1.07 ± 0.008, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|