New-generation tyrosine kinase inhibitor-associated asymptomatic cerebrovascular stenosis: two illustrative cases
| Autor: | Akihiro Hirayama, Takatoshi Sorimachi, Kittipong Srivatanakul, Hideaki Shigematsu, Kazuma Yokota, Mitsunori Matsumae |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class Constriction Pathologic Asymptomatic Magnetic resonance angiography Tyrosine-kinase inhibitor Cerebral artery stenosis chemistry.chemical_compound Internal medicine Leukemia Myelogenous Chronic BCR-ABL Positive medicine Humans Protein Kinase Inhibitors medicine.diagnostic_test Cerebral infarction business.industry Ponatinib medicine.disease respiratory tract diseases Stenosis Nilotinib chemistry Cardiology Surgery Neurology (clinical) medicine.symptom business medicine.drug |
| Zdroj: | Acta neurochirurgica. 164(6) |
| ISSN: | 0942-0940 |
| Popis: | New-generation tyrosine kinase inhibitors (TKIs), nilotinib and ponatinib, for chronic myelogenous leukemia (CML) have been reported to cause symptomatic cerebral ischemia. Herein, we report two patients with asymptomatic cerebral artery stenosis associated with these TKIs, as a previously unreported finding. Both patients were in their 40 s and administered new-generation TKIs without vascular risk factors. New-generation TKIs for CML can cause major cerebrovascular stenosis without any symptoms. Examining the neck and intracranial arteries using magnetic resonance angiography and carotid ultrasonography may prevent future cerebral infarctions associated with these TKIs. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink