Controlled, parametric, individualized, 2D and 3D imaging measurements of aerosol deposition in the respiratory tract of healthy human volunteers: in vivo data analysis
| Autor: | Livia Tossici-Bolt, John S. Fleming, Ira Katz, Spyridon Montesantos, Caroline Majoral, Marine Pichelin, Georges Caillibotte, Joy Conway |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine Adolescent Analytical chemistry Pharmaceutical Science Pilot Projects Young Adult Aerosol deposition In vivo medicine Humans Pharmacology (medical) Particle Size Lung Aged Aerosols Tomography Emission-Computed Single-Photon Inhalation business.industry Chemistry Nebulizers and Vaporizers Reproducibility of Results Technetium Equipment Design Middle Aged respiratory system Aerosol Nebulizer medicine.anatomical_structure Deposition (aerosol physics) Respiratory Mechanics Tomography Tomography X-Ray Computed Nuclear medicine business Respiratory tract |
| Popis: | Background: To provide a validation dataset for aerosol deposition modeling, a clinical trial was performed in which the inhalation parameters and the inhaled aerosol were controlled or characterized.Methods: Eleven, healthy, never-smokers, male participants completed the study. Each participant performed two inhalations of 99mTc-labeled aerosol from a vibrating mesh nebulizer, which differed by a single controlled parameter (aerosol particle size: “small” or “large”; inhalation: “deep” or “shallow”; carrier gas: air or a helium–oxygen mix). The deposition measurements were made by planar imaging, and single photon emission computed tomography–computed tomography (SPECT-CT).Results: The difference between the mean activity measured by two-dimensional imaging and that delivered from the nebulizer was 2.7%, which was not statistically significant. The total activity deposited was significantly lower in the left lung than in the right lung (pConclusions: This article presents the results of an analysis of the in vivo deposition data, obtained in a clinical study designed to provide data for model validation. This study has demonstrated the value of SPECT imaging over planar, the influence of particle size on regional distribution within the lung, and differences in deposition between the left and right lungs. |
| Databáze: | OpenAIRE |
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