Active suppression of intestinal CD4+TCRαβ+ T-lymphocyte maturation during the postnatal period
| Autor: | Mathias W. Hornef, Marijana Basic, Matthias Lochner, Olga Schulz, Reinhold Förster, Kasra Hassani, Norbert Wagner, André Bleich, Siegfried Weiss, Oliver Pabst, Anne Brennecke, Kai Yu, Tim Sparwasser, Jenny Freitag, Natalia Torow |
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| Přispěvatelé: | TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Medical School, Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Feodor-Lynen-Stra e 7, 30625 Hannover, Germany |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
CD4-Positive T-Lymphocytes
Multidisciplinary Effector Ontogeny General Physics and Astronomy Priming (immunology) Mice Transgenic General Chemistry T lymphocyte Biology Phenotype General Biochemistry Genetics and Molecular Biology Small intestine Article Immunophenotyping Intestines Immune system medicine.anatomical_structure Animals Newborn Immunology medicine Animals Growth and Development Immunity Mucosal Homeostasis |
| Zdroj: | Nature Communications Nature Communications 6, 7725 (2015). doi:10.1038/ncomms8725 |
| DOI: | 10.18154/rwth-conv-091774 |
| Popis: | Priming of the mucosal immune system during the postnatal period substantially influences host–microbial interaction and susceptibility to immune-mediated diseases in adult life. The underlying mechanisms are ill defined. Here we show that shortly after birth, CD4 T cells populate preformed lymphoid structures in the small intestine and quickly acquire a distinct transcriptional profile. T-cell recruitment is independent of microbial colonization and innate or adaptive immune stimulation but requires β7 integrin expression. Surprisingly, neonatal CD4 T cells remain immature throughout the postnatal period under homeostatic conditions but undergo maturation and gain effector function on barrier disruption. Maternal SIgA and regulatory T cells act in concert to prevent immune stimulation and maintain the immature phenotype of CD4 T cells in the postnatal intestine during homeostasis. Active suppression of CD4 T-cell maturation during the postnatal period might contribute to prevent auto-reactivity, sustain a broad TCR repertoire and establish life-long immune homeostasis. The mechanisms governing the ontogeny and maturation of the mucosal immune system during the postnatal period are not well understood. Here the authors characterize the homing kinetic, anatomical distribution and maturation of early intestinal CD4 T cells and provide insights into active T-cell suppression during the postnatal period. |
| Databáze: | OpenAIRE |
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