Synthesis and biological activity of anticoccidial agents: 2,3-diarylindoles

Autor:	Tesfaye Biftu, Dennis M. Schmatz, Penny Sue Leavitt, Paul A. Liberator, Matthew J. Wyvratt, Anne Gurnett, John Mathew, Michael H. Fisher, Donald Thompson, Gilles Ouvry, Andrew Scribner, Chris Brown, Joseph A. Moore
Rok vydání:	2009
Předmět:	Indoles Pyridines Antiparasitic medicine.drug_class Stereochemistry Clinical Biochemistry Substituent Pharmaceutical Science Biochemistry Poultry chemistry.chemical_compound In vivo Drug Discovery Cyclic GMP-Dependent Protein Kinases medicine Animals Potency Molecular Biology Indole test Coccidiosis Chemistry Organic Chemistry Biological activity Combinatorial chemistry In vitro Coccidiostats Molecular Medicine Amine gas treating Eimeria tenella
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 19:1517-1521
ISSN:	0960-894X
DOI:	10.1016/j.bmcl.2009.01.001
Popis:	Novel 2,3-diarylindoles bearing an amine substituent at the indole 5- and 6-positions have been synthesized and evaluated as anticoccidial agents in both in vitro and in vivo assays. Both subnanomolar in vitro activity and broad spectrum in vivo potency were detected for several compounds, particularly compound 27.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b89d716eae661d5308a05e327f2850b7 https://doi.org/10.1016/j.bmcl.2009.01.001 Zobrazit plný text záznamu Full Text from ScienceDirect