Angiocentric immunoproliferative lesion and angiocentric lymphoma of lymph node in children. A report of two cases
| Autor: | R Drut, R M Drut |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Male
Pathology medicine.medical_specialty Lymphomatoid granulomatosis Immunoproliferative disorder CD30 Adolescent Lymphoma T-Cell Pathology and Forensic Medicine Cervical lymphadenopathy hemic and lymphatic diseases medicine Humans Lymph node Lymphatic Diseases B cell Short Reports/Case Reports business.industry Lymphomatoid Granulomatosis General Medicine medicine.disease Immunohistochemistry Lymphoma medicine.anatomical_structure Angiocentric Immunoproliferative Lesion Child Preschool Female Lymph Nodes medicine.symptom business Immunoproliferative Disorders |
| Zdroj: | Journal of clinical pathology. 58(5) |
| ISSN: | 0021-9746 |
| Popis: | Aim: To report two examples of an angiocentric immunoproliferative lesion (AIL) and angiocentric angiodestructive lymphoma (AL) presenting in lymph nodes in children. Most commonly involving extranodal sites, AIL/AL rarely presents in the spleen and lymph nodes. Methods/Results: Case 1 presented as a cervical lymphadenopathy in a 3 year old girl being treated for pre-B cell acute lymphoblastic leukaemia. Histological and immunohistochemistry studies revealed an Epstein-Barr virus positive (EBV+), large B cell (CD20 and CD30+) AIL with large areas of necrosis, the whole resembling lymphomatoid granulomatosis. Case 2 presented as a large supraclavicular lymphadenopathy in a 13 year old boy. Histology and immunohistochemistry revealed an EBV–, large T cell (CD45RO, CD56, and CD30+) AL, presenting the features of so called angiocentric T cell/natural killer cell lymphoma, nasal type. Conclusions: The term AIL/AL refers to a heterogeneous group of conditions not unique to a particular type of lymphoid cell. These lesions are easily recognised by the histopathologist because of their extremely unusual angiocentric pattern. Although rare, AIL/AL may present as nodal lesions in children ab initio. |
| Databáze: | OpenAIRE |
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