Prognostic Value of Blood Panel Parameters in Patients With Dilated Cardiomyopathy and Advanced Heart Failure
| Autor: | A. Grande-Trillo, Diego Rangel-Sousa, José Manuel Sobrino-Márquez, E.M. Cantero-Pérez, A. Adsuar-Gómez, E. Lage-Gallé |
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| Rok vydání: | 2018 |
| Předmět: |
Cardiomyopathy
Dilated Male medicine.medical_specialty Erythrocytes Neutrophils Lymphocyte medicine.medical_treatment Cardiomyopathy 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Lymphocyte Count Heart Failure Heart transplantation Transplantation Ejection fraction Platelet Count business.industry Dilated cardiomyopathy Red blood cell distribution width Middle Aged Prognosis medicine.disease medicine.anatomical_structure 030220 oncology & carcinogenesis Heart failure Cardiology Heart Transplantation Female Surgery Observational study business Biomarkers |
| Zdroj: | Transplantation Proceedings. 50:650-652 |
| ISSN: | 0041-1345 |
| DOI: | 10.1016/j.transproceed.2017.11.060 |
| Popis: | Patients with dilated cardiomyopathy (DCM) and left ventricular dysfunction have a varied clinical course, not only dependent on left ventricular ejection fraction (LVEF) and symptoms. Finding prognostic markers for stratification in these 2 conditions is a critical area of research. Our aim was determine the prognostic value of blood panel basic parameters.We analyzed all patients with idiopathic or familial DCM and LVEF 30% coming to our heart failure unit for evaluation for non-urgent heart transplant during the period of 2009 to 2011. With 5 years of follow-up data, we could study the prognostic value of blood panel parameters. Moreover, we determined the combination of platelet count and neutrophil to lymphocyte ratio score from the BIOSTAT-CHF study.Eighty-seven patients were included in the study. After 5 years follow-up, 49 patients (57%) remain alive (group A) and 38 (43%) either died or needed a heart transplant. There were no differences between groups with regard to age or sex. Patients with good progress showed a lower red cell distribution width (RDW), a higher lymphocyte count, and a lower neutrophil/lymphocyte ratio in the initial blood panel. An RDW ≥15% was associated with long-term mortality or heart transplant.A basic blood panel could be a useful tool in assessing patients with heart failure. Larger studies are necessary to confirm our findings. A multimarker strategy could also be useful for stratification of patients with advanced heart failure. |
| Databáze: | OpenAIRE |
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