Resveratrol Inhibits Intestinal Tumorigenesis and Modulates Host-Defense-Related Gene Expression in an Animal Model of Human Familial Adenomatous Polyposis
| Autor: | Nikolaus Seiler, Yann Schneider, Rend Schleiffer, Francine Gossé, Francis Raul, B. Duranton |
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| Rok vydání: | 2001 |
| Předmět: |
Male
Cancer Research Diet therapy Medicine (miscellaneous) Resveratrol Biology medicine.disease_cause Familial adenomatous polyposis Mice chemistry.chemical_compound Immune system Intestinal Neoplasms Stilbenes Gene expression medicine Animals Anticarcinogenic Agents Cytotoxic T cell Immunity Cellular Nutrition and Dietetics Cell growth medicine.disease Mice Inbred C57BL Disease Models Animal Treatment Outcome Adenomatous Polyposis Coli Gene Expression Regulation Oncology chemistry Immunology Cancer research Carcinogenesis Cell Division |
| Zdroj: | Nutrition and Cancer. 39:102-107 |
| ISSN: | 1532-7914 0163-5581 |
| DOI: | 10.1207/s15327914nc391_14 |
| Popis: | We studied the effect of oral administration of resveratrol, a natural constituent of grapes, on tumorigenesis in Min mice. Min mice are congenic mice genetically predisposed to develop intestinal tumors as a result of a mutation of the Apc gene. Resveratrol (0.01% in the drinking water containing 0.4% ethanol) was administered for seven weeks to Min mice starting at five weeks of age. The control group was fed the same diet and received water containing 0.4% ethanol. Resveratrol prevented the formation of colon tumors and reduced the formation of small intestinal tumors by 70%. Comparison of the expression of 588 genes in the small intestinal mucosa showed that resveratrol downregulated genes that are directly involved in cell cycle progression or cell proliferation (cyclins D1 and D2, DP-1 transcription factor, and Y-box binding protein). In addition, resveratrol upregulated several genes that are involved in the recruitment and activation of immune cells (cytotoxic T lymphocyte Ag-4, leukemia inhibitory factor receptor, and monocyte chemotactic protein 3) and in the inhibition of the carcinogenic process and tumor expansion (tumor susceptibility protein TSG101, transforming growth factor-beta, inhibin-beta A subunit, and desmocollin 2). Our data highlight the complexity of the events associated with intestinal tumorigenesis and the multiplicity of the molecular targets of resveratrol. The high potency and efficacy of resveratrol support its use as a chemopreventive agent in the management of intestinal carcinogenesis. |
| Databáze: | OpenAIRE |
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