Hovenia dulcis Thumberg: Phytochemistry, Pharmacology, Toxicology and Regulatory Framework for Its Use in the European Union
Autor: | Sara Tengattini, Pasquale Pierimarchi, Fernando Tateo, Manuela Zonfrillo, Monica Bononi, Gianluca Sferrazza, Enrica Calleri, Caterina Temporini, Gloria Brusotti |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Phytochemistry
Pharmaceutical Science Review Biology Hovenia dulcis traditional medicine Analytical Chemistry lcsh:QD241-441 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Flavonols lcsh:Organic chemistry Drug Discovery media_common.cataloged_instance Physical and Theoretical Chemistry European union 030304 developmental biology media_common chemistry.chemical_classification 0303 health sciences Traditional medicine Organic Chemistry biology.organism_classification Ampelopsin chemistry Chemistry (miscellaneous) 030220 oncology & carcinogenesis visual_art Rhamnaceae visual_art.visual_art_medium regulatory science Molecular Medicine phytochemistry Bark Myricetin pharmacology toxicology |
Zdroj: | Molecules, Vol 26, Iss 903, p 903 (2021) Molecules |
ISSN: | 1420-3049 |
Popis: | Hovenia dulcis Thunberg is an herbal plant, belonging to the Rhamnaceae family, widespread in west Asia, USA, Australia and New Zealand, but still almost unknown in Western countries. H. dulcis has been described to possess several pharmacological properties, such as antidiabetic, anticancer, antioxidant, anti-inflammatory and hepatoprotective, especially in the hangover treatment, validating its use as an herbal remedy in the Chinese Traditional Medicine. These biological properties are related to a variety of secondary metabolites synthesized by the different plant parts. Root, bark and leaves are rich of dammarane-type triterpene saponins; dihydrokaempferol, quercetin, 3,3′,5′,5,7-pentahydroflavone and dihydromyricetin are flavonoids isolated from the seeds; fruits contain mainly dihydroflavonols, such as dihydromyricetin (or ampelopsin) and hovenodulinol, and flavonols such as myricetin and gallocatechin; alkaloids were found in root, barks (frangulanin) and seeds (perlolyrin), and organic acids (vanillic and ferulic) in hot water extract from seeds. Finally, peduncles have plenty of polysaccharides which justify the use as a food supplement. The aim of this work is to review the whole scientific production, with special focus on the last decade, in order to update phytochemistry, biological activities, nutritional properties, toxicological aspect and regulatory classification of H. dulcis extracts for its use in the European Union. |
Databáze: | OpenAIRE |
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