Neutrophil gelatinase-associated lipocalin as a biomarker for short-term outcomes among trauma patients: A single-center observational study

Autor: Tomoki Doi, Takeru Abe, Ichiro Takeuchi, Sakura Minami
Rok vydání: 2021
Předmět:
Male
Critical Care and Emergency Medicine
Neutrophils
Single Center
Biochemistry
law.invention
Cohort Studies
White Blood Cells
0302 clinical medicine
Animal Cells
law
Medicine and Health Sciences
Medicine
Trauma Medicine
Multidisciplinary
Middle Aged
Prognosis
Intensive care unit
Hospitals
Urinary Biomarkers
Intensive Care Units
Creatinine
030220 oncology & carcinogenesis
Cohort
Biomarker (medicine)
Female
Cellular Types
medicine.symptom
Traumatic Injury
Research Article
Adult
medicine.medical_specialty
Science
Multiple Organ Failure
Immune Cells
Urinary system
Immunology
03 medical and health sciences
Lipocalin-2
Diagnostic Medicine
Internal medicine
Humans
Aged
Blood Cells
Receiver operating characteristic
business.industry
Organ dysfunction
Biology and Life Sciences
030208 emergency & critical care medicine
Cell Biology
Health Care
ROC Curve
Health Care Facilities
Wounds and Injuries
Observational study
business
Biomarkers
Zdroj: PLoS ONE
PLoS ONE, Vol 16, Iss 5, p e0251319 (2021)
ISSN: 1932-6203
Popis: Background Urinary biomarkers for organ dysfunction could predict the outcomes of severe trauma patients. However, the use of neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker of trauma is not well studied. Objectives To evaluate the association between the short-term prognosis of trauma patients and NGAL levels. Methods We conducted a single center study and compared predictive performances between NGAL levels and the trauma severity. Results A total of 104 patients were included in the study. Patients were divided into two groups based on ISS score of 16. There was no significant difference in patient characteristics based on trauma severity. However, the lactate level was significantly higher in the more severe group. There was a significant association between urinary NGAL levels and trauma severity indicators, such as intensive care unit stay (ICU) (p = 0.005) and emergency care unit (ECU) stay (p = 0.049). In addition, receiver operating curve analysis showed that as a predictor, NGAL could be used for detecting severity with moderate precision, especially for short-term outcomes (specificity 70.6 for ICU and 69.0 for ECU stay). Conclusion In this study, we revealed that the level of NGAL could predict the degree of invasiveness in trauma patients with moderate precision and estimate the duration of treatment during the acute phase. It is necessary to examine the validity of the findings of this study using a prospective, cohort, and multi-center collaborative study design.
Databáze: OpenAIRE
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