Angiogenesis-Related Biomarkers (sFlt-1/PLGF) in the Prediction and Diagnosis of Placental Dysfunction: An Approach for Clinical Integration

Autor: Elisa Simón, Antonio García-Burguillo, José Manuel Martínez-Moratalla, Alberto Galindo, Ignacio Herraiz, Elena Ana López Jiménez, P.I. Gómez-Arriaga
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Angiogenesis
Placenta
Intrauterine growth restriction
Disease
Review
Pregnancy Proteins
Bioinformatics
lcsh:Chemistry
angiogenesis
Pre-Eclampsia
Pregnancy
lcsh:QH301-705.5
Spectroscopy
Fetal Growth Retardation
Neovascularization
Pathologic
Obstetrics
General Medicine
Prognosis
Computer Science Applications
medicine.anatomical_structure
embryonic structures
Female
medicine.medical_specialty
intrauterine growth restriction
sFlt-1
Placental insufficiency
Catalysis
Preeclampsia
Inorganic Chemistry
preeclampsia
medicine
placental insufficiency
Humans
Physical and Theoretical Chemistry
Molecular Biology
Abruptio Placentae
Placenta Growth Factor
Vascular Endothelial Growth Factor Receptor-1
Placental abruption
business.industry
Organic Chemistry
medicine.disease
placental abruption
lcsh:Biology (General)
lcsh:QD1-999
PlGF
business
Biomarkers
Zdroj: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 16, Iss 8, Pp 19009-19026 (2015)
ISSN: 1422-0067
Popis: Placental dysfunction is involved in a group of obstetrical conditions including preeclampsia, intrauterine growth restriction, and placental abruption. Their timely and accurate recognition is often a challenge since diagnostic criteria are still based on nonspecific signs and symptoms. The discovering of the role of angiogenic-related factors (sFlt-1/PlGF) in the underlying pathophysiology of placental dysfunction, taking into account that angiogenesis-related biomarkers are not specific to any particular placental insufficiency-related disease, has marked an important step for improving their early diagnosis and prognosis assessment. However, sFlt-1/PlGF has not been yet established as a part of most guidelines. We will review the current evidence on the clinical utility of sFlt-1/PlGF and propose a new protocol for its clinical integration.
Databáze: OpenAIRE
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