The influence of adipose tissue on spatially resolved near-infrared spectroscopy derived skeletal muscle oxygenation: the extent of the problem

Autor: Victor M. Niemeijer, Pieter F. F. Wijn, Jasper P. Jansen, Thomas C. van Dijk, Hareld M. C. Kemps, Ruud F. Spee, Eduard J. Meijer
Přispěvatelé: School of Med. Physics and Eng. Eindhoven
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Male
Heart Failure/metabolism
Physiology
Adipose tissue
030204 cardiovascular system & hematology
0302 clinical medicine
Nuclear magnetic resonance
gender
Near-Infrared
80 and over
030212 general & internal medicine
oxygen kinetics
Spectroscopy
Aged
80 and over
Spectroscopy
Near-Infrared
exercise
Chemistry
Venous blood
Middle Aged
chronic heart failure
medicine.anatomical_structure
Adipose Tissue
Muscle
Female
Adipose Tissue/cytology
Saturation (chemistry)
Perfusion
Adult
Biomedical Engineering
Biophysics
Skeletal/metabolism
03 medical and health sciences
In vivo
blood
Physiology (medical)
medicine
Humans
Muscle
Skeletal
Aged
Heart Failure
Muscle
Skeletal/metabolism
aging
Skeletal muscle
Oxygenation
medicine.disease
Oxygen/metabolism
Oxygen
Heart failure
Case-Control Studies
Chronic Disease
Zdroj: Physiological Measurement, 38(3), 539-554. Institute of Physics
ISSN: 0967-3334
Popis: Objective. Near-infrared spectroscopy (NIRS) measurements of tissue oxygen saturation (StO2) are useful for the assessment of skeletal muscle perfusion and function during exercise, however, they are influenced by overlying skin and adipose tissue. This study explored the extent and nature of the influence of adipose tissue thickness (ATT) on StO2. Approach. NIR spatially resolved spectroscopy (SRS) derived oxygenation was measured on vastus lateralis in 56 patients with chronic heart failure (CHF) and 20 healthy control (HC) subjects during rest and moderate intensity exercise with simultaneous assessment of oxygen uptake kinetics (τ ). In vitro measurements were performed on a flow cell with a blood mixture with full oxygen saturation (100%), which was gradually decreased to 0% by adding sodium metabisulfite. Experiments were repeated with 2 mm increments of porcine fat layer between the NIRS device and flow cell up to 14 mm. Main results. Lower ATT, higher τ , and CHF were independently associated with lower in vivo StO2 in multiple regression analysis, whereas age and gender showed no independent relationship. With greater ATT, in vitro StO2 was reduced from 100% to 74% for fully oxygenated blood and increased from 0% to 68% for deoxygenated blood. Significance. This study shows that ATT independently confounds NIR-SRS derived StO2 by overestimating actual skeletal muscle oxygenation and by decreasing its sensitivity for deoxygenation. Because physiological properties (e.g. presence of disease and slowing of τ ) also influence NIR-SRS, a correction based on optical properties is needed to interpret calculated values as absolute StO2.
Databáze: OpenAIRE
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