Global alternans instability and its effect on non-linear wave propagation : dynamical Wenckebach block and self terminating spiral waves
| Autor: | Alexander V. Panfilov, Arne Defauw, Peter Dawyndt, Nele Vandersickel |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
CIRCUS MOVEMENT Action Potentials RESTITUTION 030204 cardiovascular system & hematology 01 natural sciences Instability Article CARDIAC 03 medical and health sciences 0302 clinical medicine DISPERSION Internal medicine 0103 physical sciences EXCITATION medicine Repolarization Humans 010306 general physics Dispersion (water waves) Spiral Physics Multidisciplinary Models Cardiovascular Arrhythmias Cardiac Mechanics REPOLARIZATION medicine.disease Pulse (physics) MODEL Nonlinear system Reentrancy Nonlinear Dynamics Physics and Astronomy TISSUE CONDUCTION Ventricular fibrillation ATRIAL-FIBRILLATION Cardiology cardiovascular system VENTRICULAR-FIBRILLATION |
| Zdroj: | SCIENTIFIC REPORTS Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | The main mechanism of formation of reentrant cardiac arrhythmias is via formation of waveblocks at heterogeneities of cardiac tissue. We report that heterogeneity and the area of waveblock can extend itself in space and can result formation of new additional sources, or termination of existing sources of arrhythmias. This effect is based on a new form of instability, which we coin as global alternans instability (GAI). GAI is closely related to the so-called (discordant) alternans instability, however its onset is determined by the global properties of the APD-restitution curve and not by its slope. The APD-restitution curve relates the duration of the cardiac pulse (APD) to the time interval between the pulses and can easily be measured in an experimental or even clinical setting. We formulate the conditions for the onset of GAI, study its manifestation in various 1D and 2D situations and discuss its importance for the onset of cardiac arrhythmias. |
| Databáze: | OpenAIRE |
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