Histone editing elucidates the functional roles of H3K27 methylation and acetylation in mammals

Autor:	Aditya Sankar, Faizaan Mohammad, Arun Kumar Sundaramurthy, Hua Wang, Mads Lerdrup, Tulin Tatar, Kristian Helin
Rok vydání:	2022
Předmět:	Histones Mammals Mice Drosophila melanogaster Polycomb Repressive Complex 2 Genetics Animals Acetylation Methylation Protein Processing Post-Translational Chromatin Article
Zdroj:	Nat Genet
ISSN:	1546-1718 1061-4036
DOI:	10.1038/s41588-022-01091-2
Popis:	A new study employs CRISPR/Cas9-based base editing for simultaneous mutagenesis of all copies of histone H3 genes in mammals, highlighting the functional importance of H3K27me3 for Polycomb-mediated gene silencing and the dispensability for H3K27ac in transcriptional activation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b897405c6663ad9f80a2824ad46026b7 https://doi.org/10.1038/s41588-022-01091-2 Zobrazit plný text záznamu Full text from SpringerLink