Chronic Lymphocytic Leukemia of the Aortic Valve: A Case Report
| Autor: | Jeffrey Jordan, Marie-Louise Posch, Sean-Patrick Prince, Kevin Thompson, Fagunkumar Modi |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Aortic valve
Pathology medicine.medical_specialty Chronic lymphocytic leukemia 030204 cardiovascular system & hematology Asymptomatic 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine immune system diseases hemic and lymphatic diseases Internal Medicine medicine neoplasms cll CD20 biology business.industry leukemia General Engineering Hematology medicine.disease Leukemia medicine.anatomical_structure Oncology chemistry lymphocytic Ibrutinib biology.protein Bone marrow medicine.symptom CD5 aortic business valve 030217 neurology & neurosurgery |
| Zdroj: | Cureus |
| ISSN: | 2168-8184 |
| Popis: | Chronic lymphocytic leukemia (CLL) is characterized by the chronic accumulation of mature B-cell lymphocytes in the bone marrow. CLL accounts for approximately one-quarter of new leukemia cases each year and is the most common leukemia in Western countries. Most notably, this leukemia involves the lymph nodes, spleen, and liver, whereas non-lymphoid tissue is seldom associated with CLL infiltration. A large percentage of patients are asymptomatic at presentation; however, for those who are symptomatic, lymphadenopathy is the most common presenting complaint. This is the case of a 75-year-old Caucasian male with CLL on ibrutinib who presented with chest pressure and worsening shortness of breath. The patient underwent cardiac catheterization, which revealed demonstrable aortic stenosis. His aortic valve was subsequently replaced, and tissue was sent for histochemical analysis. Stains were positive for CD20, BCL2, CD5, and CD23, compatible with the CLL of the valve. To be able to investigate those with a known leukemic disease in patients with valvular disease would be beneficial to clinicians as CLL can present in atypical locations. |
| Databáze: | OpenAIRE |
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