Rare tautomers of 1-methyluracil and 1-methylthymine: tuning relative stabilities through coordination to PtII complexes

Autor: F. Matthias Bickelhaupt, Tushar van der Wijst, Bernhard Lippert, Marcel Swart, Célia Fonseca Guerra
Přispěvatelé: AIMMS, Theoretical Chemistry
Rok vydání: 2008
Předmět:
Zdroj: van der Wijst, T, Guerra, C F, Swart, M, Bickelhaupt, F M & Lippert, B 2008, ' Rare Tautomers of 1-Methyluracil and 1-Methylthymine: Tuning Relative Stabilities through Coordination to Pt-II Complexes ', Chemistry: A European Journal, vol. 15, no. 1, pp. 209-218 . https://doi.org/10.1002/chem.200801476
Chemistry: A European Journal, 15(1), 209-218. Wiley-VCH Verlag
ISSN: 1521-3765
0947-6539
DOI: 10.1002/chem.200801476
Popis: We have computationally explored how the relative stabilities of 1-methyluracil (1-MeUH) tautomers can be tuned through coordination of these tautomers to Pt(II) complexes with a particular set of ligands. This has been done using density functional theory at the BP86/TZ2P level. Thus, we have examined the water/1-MeUH exchange reactions of [Pt(II)(A)(B)(C)(OH(2))](q) + 1-MeUH to uncover: i) which tautomers are best stabilized by the Pt(II) complex, and ii) how the net charge q in the complex affects the reaction energy. The net charge q depends on the ligands A, B, and C, which can be the neutral NH(3) or anionic Cl(-). To reveal the effect of solvation, all reaction systems are studied both in the gas phase and in water. Also the stabilization of tautomers of 1-methylthymine (1-MeTH) by cisplatin is investigated. The calculations reveal that relative energies of the metal (here: Pt(II))-complexed forms of the various tautomers (here: of 1-MeUH and 1-MeTH) do not parallel those of the free tautomers. Rather, a rare nucleobase tautomer, despite its low natural abundance, may become favored over the predominant one when complexed to a metal ion.
Databáze: OpenAIRE
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