Fatigue in Children With Sickle Cell Disease
| Autor: | Melanie J. Bonner, Lindsay M. Anderson, Taryn M. Allen, Courtney D. Thornburg |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Parents medicine.medical_specialty Adolescent Anemia Sickle Cell Child Behavior Disorders Disease Severity of Illness Index Executive Function Quality of life Severity of illness Social emotional learning Humans Medicine Affective Symptoms Child Social Behavior Fatigue Pain Measurement Intelligence Tests Memory Disorders Intelligence quotient Working memory business.industry Chronic pain Hematology medicine.disease Hospitalization Memory Short-Term Caregivers Oncology Pediatrics Perinatology and Child Health Quality of Life Physical therapy Female Self Report Chronic Pain Cognition Disorders business Attitude to Health Neurocognitive |
| Zdroj: | Journal of Pediatric Hematology/Oncology. 37:584-589 |
| ISSN: | 1077-4114 |
| DOI: | 10.1097/mph.0000000000000431 |
| Popis: | Children with sickle cell disease (SCD) report fatigue in addition to acute and chronic pain, which can decrease overall health-related quality of life (HRQL). The primary objective of the current study was to investigate the relationship between fatigue and HRQL. Given limited prior research, secondary objectives included investigation of associations between fatigue and functional outcomes, including child neurocognitive and social-emotional functioning. Children aged 8 to 16 years (N=32) and a caregiver completed measures of fatigue, HRQL, pain, and neurocognitive and social-emotional functioning. Controlling for pain and number of SCD-related hospitalizations, hierarchical linear regression models were used to determine the impact of child-reported and parent-reported fatigue on child HRQL. Correlational analyses were used to explore the relationship between fatigue and additional child outcomes. Data indicated that children with SCD experience clinically relevant levels of fatigue, which independently predicts lower HRQL. Fatigue was also associated with lower working memory, executive functioning, and higher levels of internalizing symptoms. Given its observed impact on HRQL and relationship to functional outcomes, fatigue may be an important target of clinical, home, or school interventions. This practice may attenuate the burden of fatigue in these patients, and in turn, help improve the quality of life of children living with SCD. |
| Databáze: | OpenAIRE |
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