Association of findings in flow-volume spirometry with high-resolution computed tomography signs in asbestos-exposed male workers

Autor: Leena Kivisaari, Simo Kaleva, Anssi Sovijärvi, Olli Huuskonen, Tapio Vehmas, Päivi Piirilä
Rok vydání: 2009
Předmět:
Adult
Male
Spirometry
High-resolution computed tomography
Vital capacity
medicine.medical_specialty
Physiology
Pulmonary Fibrosis
Vital Capacity
Pulmonary function testing
03 medical and health sciences
FEV1/FVC ratio
0302 clinical medicine
Predictive Value of Tests
Forced Expiratory Volume
Occupational Exposure
Physiology (medical)
medicine
Humans
Lung volumes
Lung
Pathological
Aged
Aged
80 and over
medicine.diagnostic_test
Construction Materials
business.industry
Smoking
Total Lung Capacity
Respiratory disease
Asbestos
General Medicine
Middle Aged
respiratory system
medicine.disease
030210 environmental & occupational health
respiratory tract diseases
3. Good health
Pulmonary Emphysema
030228 respiratory system
Asbestosis
Radiology
Pulmonary Ventilation
business
Tomography
Spiral Computed
Zdroj: Clinical Physiology and Functional Imaging. 29:1-9
ISSN: 1475-097X
1475-0961
DOI: 10.1111/j.1475-097x.2008.00827.x
Popis: Summary Introduction: Disorders of pulmonary tissue and pleura are visualized by findings in high-resolution computed tomography (HRCT), and the impairment caused by these findings is assessed by pulmonary function tests. Our aim was to determine how some commonly used spirometric variables are related to certain HRCT signs, in order to find out which HRCT signs are associated with restrictive and which with obstructive ventilatory impairment. Methods: Altogether 590 asbestos-exposed workers, 95% of whom were smokers or ex-smokers, were studied with HRCT; 19 pathological signs were scored. Forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), FEV1/FVC ratio, forced expiratory flow at 50% of FVC (MEF50) and total lung capacity (TLC) were measured, and their relationship with HRCT signs was examined with bivariate correlations and multiple regression analysis. Results: FVC and TLC were negatively correlated with fibrosis score, parenchymal bands, extent of pleural thickenings and positively with widened retrosternal space. FEV1/FVC ratio was negatively correlated with emphysema types and widened retrosternal space and positively with parenchymal bands and subpleural nodules. Thickened bronchial walls did not separate between restrictive and obstructive ventilatory function. Conclusions: HRCT signs showed distinctive patterns in restrictive and obstructive ventilatory impairment. These results can be used to help to analyse the lung function of patients simultaneously exposed to asbestos and smoking, when this relationship requires elucidation. In addition, the results may be helpful in explaining some radiological findings.
Databáze: OpenAIRE
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