Neurogenesis in the adult Drosophila brain
| Autor: | Kassi L. Crocker, Stacey A. Rimkus, Khailee Marischuk, Jerry C.P. Yin, Grace Boekhoff-Falk, Hong Zhou |
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| Rok vydání: | 2021 |
| Předmět: |
Traumatic brain injury
Neurogenesis Nerve Tissue Proteins Biology Neural Stem Cells Neuroblast Brain Injuries Traumatic Basic Helix-Loop-Helix Transcription Factors Genetics medicine Animals Drosophila Proteins Regeneration Axon Neurodegeneration Human brain medicine.disease Axons DNA-Binding Proteins Drosophila melanogaster medicine.anatomical_structure Neuron Stem cell Neuroglia Neuroscience |
| Zdroj: | Genetics. 219 |
| ISSN: | 1943-2631 |
| Popis: | Neurodegenerative diseases such as Alzheimer’s and Parkinson’s currently affect ∼25 million people worldwide. The global incidence of traumatic brain injury (TBI) is estimated at ∼70 million/year. Both neurodegenerative diseases and TBI remain without effective treatments. We are utilizing adult Drosophila melanogaster to investigate the mechanisms of brain regeneration with the long-term goal of identifying targets for neural regenerative therapies. We specifically focused on neurogenesis, i.e., the generation of new cells, as opposed to the regrowth of specific subcellular structures such as axons. Like mammals, Drosophila have few proliferating cells in the adult brain. Nonetheless, within 24 hours of a penetrating traumatic brain injury (PTBI) to the central brain, there is a significant increase in the number of proliferating cells. We subsequently detect both new glia and new neurons and the formation of new axon tracts that target appropriate brain regions. Glial cells divide rapidly upon injury to give rise to new glial cells. Other cells near the injury site upregulate neural progenitor genes including asense and deadpan and later give rise to the new neurons. Locomotor abnormalities observed after PTBI are reversed within 2 weeks of injury, supporting the idea that there is functional recovery. Together, these data indicate that adult Drosophila brains are capable of neuronal repair. We anticipate that this paradigm will facilitate the dissection of the mechanisms of neural regeneration and that these processes will be relevant to human brain repair. |
| Databáze: | OpenAIRE |
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