Two new nor-sesquiterpenoids from Fusarium tricinctum, an endophytic fungus isolated from Ligusticum chuanxiong

Autor:	Da-Le Guo, Yu-Cheng Gu, Meng-Ying Jin, Fang Deng, Zhi-Xing Cao, Tian-Long Yang, Yun Deng, Yu-Mei Cao, Lu Tan, Xiao-Hua Li
Rok vydání:	2020
Předmět:	Ligusticum chuanxiong 010405 organic chemistry Chemistry Stereochemistry Organic Chemistry Fusarium tricinctum Plant Science Endophytic fungus 01 natural sciences Biochemistry 0104 chemical sciences Analytical Chemistry 010404 medicinal & biomolecular chemistry Moiety Cytotoxicity
Zdroj:	Natural Product Research. 35:3535-3539
ISSN:	1478-6427 1478-6419
Popis:	As part of our search for compounds with cytotoxicity from endophytes of traditional Chinese medicines, two novel nor-sesquiterpenoids (1–2) with a new skeleton containing a tetrahydrofuran moiety were isolated form a rice medium of Fusarium tricinctum, an endophytic fungus isolated from the root of Ligusticum chuanxiong. The structures of these two previously undescribed compounds were elucidated by interpretation of the spectroscopic evidences including NMR correlations as well as MS data. The absolute configurations of these two compounds were confirmed by TD-DFT-ECD calculations. An MTT assay indicated that compound 1 exhibited moderate cytotoxic activity against MV4-11 with an IC50 value of 22.29 μM.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b890415bdb52dfa925de6a9eef3b126a https://doi.org/10.1080/14786419.2020.1712385 Zobrazit plný text záznamu