Swine Influenza Virus (H1N2) Characterization and Transmission in Ferrets, Chile

Autor: Erik A. Karlsson, Pedro Jimenez-Bluhm, Valerie Cortez, Melinda A. Beck, Pamela Freiden, Bryan S. Kaplan, Christopher Hamilton-West, Stacey Schultz-Cherry, Victoria A. Meliopoulos, Nicolas Bravo-Vasquez, Shauna A. Marvin
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
Epidemiology
Swine
viruses
lcsh:Medicine
medicine.disease_cause
Antibodies
Viral
Virus Replication
backyard production system
Animal Diseases
Seroepidemiologic Studies
Public Health Surveillance
Chile
Geography
Medical
influenza A
Swine Diseases
biology
Transmission (medicine)
H1N2
Antibody titer
transmission
High-Throughput Nucleotide Sequencing
H1N1 pandemic strain
Infectious Diseases
RNA
Viral
Female
Seasons
influenza
Microbiology (medical)
Swine Influenza Virus (H1N2) Characterization and Transmission in Ferrets
Chile
030106 microbiology
Hemagglutinin (influenza)
H5N1 genetic structure
Virus
backyard farm
lcsh:Infectious and parasitic diseases
Cell Line
03 medical and health sciences
swine influenza virus
Orthomyxoviridae Infections
Influenza A Virus
H1N2 Subtype
Influenza
Human
medicine
Animals
Humans
lcsh:RC109-216
Hemagglutination assay
Research
lcsh:R
Ferrets
South America
Hemagglutination Inhibition Tests
Virology
Influenza A virus subtype H5N1
zoonoses
030104 developmental biology
biology.protein
Neuraminidase
Zdroj: Emerging Infectious Diseases
Emerging Infectious Diseases, Vol 23, Iss 2, Pp 241-251 (2017)
DOI: 10.17615/fyad-0410
Popis: Phylogenetic analysis of the influenza hemagglutinin gene (HA) has suggested that commercial pigs in Chile harbor unique human seasonal H1-like influenza viruses, but further information, including characterization of these viruses, was unavailable. We isolated influenza virus (H1N2) from a swine in a backyard production farm in Central Chile and demonstrated that the HA gene was identical to that in a previous report. Its HA and neuraminidase genes were most similar to human H1 and N2 viruses from the early 1990s and internal segments were similar to influenza A(H1N1)pdm09 virus. The virus replicated efficiently in vitro and in vivo and transmitted in ferrets by respiratory droplet. Antigenically, it was distinct from other swine viruses. Hemagglutination inhibition analysis suggested that antibody titers to the swine Chilean H1N2 virus were decreased in persons born after 1990. Further studies are needed to characterize the potential risk to humans, as well as the ecology of influenza in swine in South America.
Databáze: OpenAIRE
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