CYP2C19haplotypes in Koreans as a marker of enzyme activity evaluated with omeprazole
| Autor: | J.‐I. Kim, Sun Kyung Jin, Tae Sun Kang, Hwa Jeong Lee, Jaesook Roh, S. O. Eom |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.drug_class Population Administration Oral Proton-pump inhibitor Single-nucleotide polymorphism CYP2C19 Pharmacology Polymorphism Single Nucleotide Gastroenterology 2-Pyridinylmethylsulfinylbenzimidazoles Young Adult Asian People Pharmacokinetics Internal medicine medicine Humans Pharmacology (medical) Allele education Alleles Omeprazole education.field_of_study Korea Chemistry Haplotype Anti-Ulcer Agents Cytochrome P-450 CYP2C19 Haplotypes Area Under Curve Female Aryl Hydrocarbon Hydroxylases Half-Life medicine.drug |
| Zdroj: | Journal of Clinical Pharmacy and Therapeutics. 34:437-446 |
| ISSN: | 1365-2710 0269-4727 |
| Popis: | Summary Background and objective: CYP2C19 is clinically important in Korea because of the relatively high incidence of poor metabolizers in the population. To fully understand the genetic mechanism of the CYP2C19 defect in poor metabolizers, all variants need to be studied simultaneously. The aim of this study was to investigate the usefulness of CYP2C19 haplotypes as a marker of CYP2C19 enzyme activity in Koreans. Methods: We analysed the single nucleotide polymorphisms and haplotypes of the CYP2C19 gene in 150 healthy Koreans and found three major (frequency > 0·1) haplotypes (H1, H2 and H3). One oral dose of 40 mg omeprazole (Losec®) was administered to 30 subjects grouped as H1/H1, H2/H2, H1/H2, H1/H3 and H2/H3. The pharmacokinetics of omeprazole and its metabolites, 5-hydroxyomeprazole and omeprazole sulphone, in those groups was analysed. Results and discussion: The area under the plasma concentration–time curve (AUC0∞) and elimination half-life (T1/2) of omeprazole were significantly greater in the H2/H2 and H2/H3 groups than in the H1/H1 group (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|