Parental imprinting effect at the INS-IGF2 diabetes susceptibility locus
| Autor: | Eleanor Colle, Asterios Kukuvitis, Constantin Polychronakos, Nick Giannoukakis |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
Genetic Markers Male Heterozygote Genotype Genetic Linkage Endocrinology Diabetes and Metabolism Locus (genetics) Biology Polymerase Chain Reaction Genomic Imprinting Insulin-Like Growth Factor II Odds Ratio Internal Medicine Humans Insulin Genetic Predisposition to Disease Imprinting (psychology) Allele Child Gene Alleles Genetic association Genetics Chromosomes Human Pair 11 Haplotype Chromosome Mapping Diabetes Mellitus Type 1 Haplotypes Insulin-like growth factor 2 biology.protein Female Genomic imprinting Polymorphism Restriction Fragment Length |
| Zdroj: | Diabetologia. 38:715-719 |
| ISSN: | 1432-0428 0012-186X |
| DOI: | 10.1007/bf00401845 |
| Popis: | Although association of insulin-dependent diabetes mellitus with a haplotype at a locus encompassing the genes for insulin and the insulin-like growth factor II has been well established, two major studies disagree as to whether linkage to this locus is confined to paternally inherited alleles, or is present in alleles transmitted from either parental sex. Towards resolving this discrepancy, we examined parent-of-origin specific association rather than linkage, using the haplotype relative risk method in a mixed Caucasian population. We find that the haplotype relative risk (HRR) conferred by paternal chromosomes was much higher (5.1, p0.01) than the corresponding maternal value (2.3, p = 0.07), which narrowly failed to reach statistical significance. Thus, although we cannot exclude an effect of the maternal allele, such an effect appears to be considerably weaker. We review evidence that parental imprinting is genotype-dependent, which may explain the different degrees to which the paternal effect is seen in different populations. |
| Databáze: | OpenAIRE |
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