Stimulation of Microsomal Drug Oxidation in Liver and Kidney of Rats Treated with the Oncolytic Agent cis-Dichlorodiammineplatinum-II
| Autor: | Samuel Tong, Zahid H. Siddik, Charles L. Litterst, Yoichiro Hirokata |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
medicine.medical_specialty
Time Factors Thiobarbituric acid medicine.medical_treatment Intraperitoneal injection Pharmacology Kidney Mixed Function Oxygenases chemistry.chemical_compound Cytochrome P-450 Enzyme System Microsomes Internal medicine medicine Animals Aniline Hydroxylase biology Rats Inbred Strains General Medicine Metabolism In vitro Enzyme assay Rats Endocrinology Pharmaceutical Preparations chemistry Organ Specificity Microsomes Liver Microsome biology.protein Female Cisplatin Oxidation-Reduction Drug metabolism |
| Zdroj: | Pharmacology. 26:46-53 |
| ISSN: | 1423-0313 0031-7012 |
| Popis: | In vitro drug metabolism from liver and kidney of rats was studied for up to 12 days following a single intraperitoneal injection of the antineoplastic drug cisplatinum. At 3,5, and 8 days posttreatment, hepatic cytochrome P-450 dependent enzyme activity was increased 20-45%, but levels of cytochromes P-450 and b5 were unaltered. Hepatic in vitro stimulated thiobarbituric acid reactive (TBAR) substances were increased at all times, with a maximum of 20 times normal on day 5. Renal aniline hydroxylase activity was elevated 25-95% throughout the first 8 days. Renal in vitro stimulated TBAR substances were not significantly altered. In vitro addition of cisPt to control microsomes resulted in no consistent, dose-related changes in substrate metabolism. |
| Databáze: | OpenAIRE |
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