Stimulation of Microsomal Drug Oxidation in Liver and Kidney of Rats Treated with the Oncolytic Agent cis-Dichlorodiammineplatinum-II

Autor: Samuel Tong, Zahid H. Siddik, Charles L. Litterst, Yoichiro Hirokata
Rok vydání: 1983
Předmět:
Zdroj: Pharmacology. 26:46-53
ISSN: 1423-0313
0031-7012
Popis: In vitro drug metabolism from liver and kidney of rats was studied for up to 12 days following a single intraperitoneal injection of the antineoplastic drug cisplatinum. At 3,5, and 8 days posttreatment, hepatic cytochrome P-450 dependent enzyme activity was increased 20-45%, but levels of cytochromes P-450 and b5 were unaltered. Hepatic in vitro stimulated thiobarbituric acid reactive (TBAR) substances were increased at all times, with a maximum of 20 times normal on day 5. Renal aniline hydroxylase activity was elevated 25-95% throughout the first 8 days. Renal in vitro stimulated TBAR substances were not significantly altered. In vitro addition of cisPt to control microsomes resulted in no consistent, dose-related changes in substrate metabolism.
Databáze: OpenAIRE