Zeb2 is essential for Schwann cell differentiation, myelination and nerve repair
| Autor: | Danny Huylebroeck, Franziska Fröb, Klaus-Armin Nave, Madlen Ebert, Michael W. Sereda, Victor Tarabykin, Ueli Suter, Susanne Quintes, Michael Wegner, Friederike A. Arlt, Dies Meijer, Bastian G. Brinkmann, Theresa Kungl |
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| Přispěvatelé: | Cell biology |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
SOX10 Schwann cell Mice Transgenic Biology Article 03 medical and health sciences Myelin 0302 clinical medicine SOX2 Peripheral Nerve Injuries medicine Animals Peripheral Nerves Remyelination Early Growth Response Protein 2 Myelin Sheath Zinc Finger E-box Binding Homeobox 2 Homeodomain Proteins General Neuroscience Regeneration (biology) Cell Differentiation Axons Nerve Regeneration Repressor Proteins 030104 developmental biology medicine.anatomical_structure nervous system Peripheral nerve injury Schwann cell differentiation Schwann Cells Neuroscience 030217 neurology & neurosurgery Transcription Factors |
| Zdroj: | Nature neuroscience Quintes, S, Brinkmann, B G, Ebert, M, Fröb, F, Kungl, T, Arlt, F A, Tarabykin, V, Huylebroeck, D, Meijer, D, Suter, U, Wegner, M, Sereda, M W & Nave, K-A 2016, ' Zeb2 is essential for Schwann cell differentiation, myelination and nerve repair ', Nature Neuroscience, vol. 19, no. 8, pp. 1050–1059 . https://doi.org/10.1038/nn.4321 Nature Neuroscience Nature Neuroscience, 19(8), 1050-+. Nature Publishing Group Europe PubMed Central |
| ISSN: | 1546-1726 1097-6256 |
| DOI: | 10.1038/nn.4321 |
| Popis: | Schwann cell development and peripheral nerve myelination require the serial expression of transcriptional activators, such as Sox10, Oct6 (also called Scip or Pou3f1) and Krox20 (also called Egr2). Here we show that transcriptional repression, mediated by the zinc-finger protein Zeb2 (also known as Sip1), is essential for differentiation and myelination. Mice lacking Zeb2 in Schwann cells develop a severe peripheral neuropathy, caused by failure of axonal sorting and virtual absence of myelin membranes. Zeb2-deficient Schwann cells continuously express repressors of lineage progression. Moreover, genes for negative regulators of maturation such as Sox2 and Ednrb emerge as Zeb2 target genes, supporting its function as an 'inhibitor of inhibitors' in myelination control. When Zeb2 is deleted in adult mice, Schwann cells readily dedifferentiate following peripheral nerve injury and become repair cells. However, nerve regeneration and remyelination are both perturbed, demonstrating that Zeb2, although undetectable in adult Schwann cells, has a latent function throughout life. |
| Databáze: | OpenAIRE |
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