Management Recommendations for Merkel Cell Carcinoma—A Danish Perspective

Autor: Simon Naseri, Lisbet Rosenkrantz Hölmich, Niels Junker, Seppo W. Langer, Torben Steiniche, Morten Ladekarl, Alessandro Venzo, Marie Louise Bønnelykke-Behrndtz, Mathilde S. Larsen, Elizaveta Mitkina Tabaksblat, Annette H. Chakera, Siri Klausen
Rok vydání: 2020
Předmět:
Zdroj: Naseri, S, Steiniche, T, Ladekarl, M, Bønnelykke-Behrndtz, M L, Hölmich, L R, Langer, S W, Venzo, A, Tabaksblat, E, Klausen, S, Skaarup Larsen, M, Junker, N & Chakera, A H 2020, ' Management Recommendations for Merkel Cell Carcinoma-A Danish Perspective ', Cancers, vol. 12, no. 3, 554 . https://doi.org/10.3390/cancers12030554
Cancers, Vol 12, Iss 3, p 554 (2020)
Naseri, S, Steiniche, T, Ladekarl, M, Bønnelykke-Behrndtz, M L, Hölmich, L R, Langer, S W, Venzo, A, Tabaksblat, E, Klausen, S, Larsen, M S, Junker, N & Chakera, A H 2020, ' Management recommendations for merkel cell carcinoma : a Danish perspective ', Cancers, vol. 12, no. 3, 554 . https://doi.org/10.3390/cancers12030554
Cancers
Naseri, S, Steiniche, T, Ladekarl, M, Bønnelykke-Behrndtz, M L, Hölmich, L R, Langer, S W, Venzo, A, Tabaksblat, E, Klausen, S, Larsen, M S, Junker, N & Chakera, A H 2020, ' Management Recommendations for Merkel Cell Carcinoma : A Danish Perspective ', Cancers, vol. 12, no. 3, 554 . https://doi.org/10.3390/cancers12030554
ISSN: 2072-6694
Popis: Merkel cell carcinoma (MCC) is a rare malignant neuroendocrine carcinoma of the skin with a poor prognosis and an apparent increase in incidence. Due to its rarity, evidence-based guidelines are limited, and there is a lack of awareness among clinicians. This review constitutes the consensus management recommendations developed by the Danish MCC expert group and is based on a systematic literature search. Patients with localized disease are recommended surgical excision and adjuvant radiotherapy to the primary site; however, this may be omitted in patients with MCC with low risk features. Patients with regional lymph node involvement are recommended complete lymph node removal and adjuvant radiotherapy in case of extracapsular disease. Metastatic disease was traditionally treated with chemotherapy, however, recent clinical trials with immune therapy have been promising. Immune checkpoint inhibitors targeting the programmed cell death protein 1(PD-1)/programmed death-ligand 1(PD-L1) axis should therefore be strongly considered as first-line treatment for fit patients. A 5-year follow-up period is recommended involving clinical exam every 3 months for 2 years and every 6 months for the following 3 years and PET-CT one to two times a year or if clinically indicated. These national recommendations are intended to offer uniform patient treatment and hopefully improve prognosis.
Databáze: OpenAIRE
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