Is Primary Androgen Deprivation Therapy a Suitable Option for Asian Patients With Prostate Cancer Compared With Radical Prostatectomy?
| Autor: | Seung Hwan Lee, Seong Il Seo, Minjoo Kang, Seung-Ju Lee, Shinhee Kang, Jeonghoon Ahn, Jooyeon Park, U-Syn Ha, Jangmi Yang, Byung Ha Chung, Cheol Kwak, Ji Youl Lee, Seok-Soo Byun, Chang Wook Jeong, Jin Bong Choi, Eun Jung Park, Hyun Moo Lee, Insun Choi, Choung Soo Kim, Jung Im Shim |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Oncology medicine.medical_specialty medicine.medical_treatment Clinical Decision-Making 030232 urology & nephrology Kaplan-Meier Estimate Androgen deprivation therapy 03 medical and health sciences Prostate cancer 0302 clinical medicine Internal medicine medicine Humans Stage (cooking) Survival analysis Aged Proportional Hazards Models Retrospective Studies Aged 80 and over Prostatectomy business.industry Proportional hazards model Disease Management Prostatic Neoplasms Androgen Antagonists Middle Aged Prognosis medicine.disease Cancer registry Treatment Outcome Population Surveillance 030220 oncology & carcinogenesis Cohort business |
| Zdroj: | Journal of the National Comprehensive Cancer Network. 17:441-449 |
| ISSN: | 1540-1413 1540-1405 |
| DOI: | 10.6004/jnccn.2018.7265 |
| Popis: | Background: We conducted a comparative survival analysis between primary androgen deprivation therapy (PADT) and radical prostatectomy (RP) based on nationwide Korean population data that included all patients with prostate cancer. Materials and Methods: This study enrolled 4,538 patients with prostate cancer from the National Health Insurance Service (NHIS) database linked with Korean Central Cancer Registry data who were treated with PADT or RP between January 1, 2007, and December 31, 2014. Kaplan-Meier and multivariate survival analyses stratified by stage (localized and locally advanced) and age (Results: Among 18,403 patients from the NHIS database diagnosed with prostate cancer during the study period, 4,538 satisfied inclusion criteria and were included in the analyses. Of these, 3,136 and 1,402 patients underwent RP or received PADT, respectively. Risk of death was significantly increased for patients who received PADT compared with those who underwent RP in the propensity score–matched cohort. In subgroup analyses stratified by stage and age, in every subgroup, patients who received PADT had a significantly increased risk of death compared with those who underwent RP. In particular, a much greater risk was observed for patients with locally advanced prostate cancer. Conclusions: Based on a nationwide survival analysis of nonmetastatic prostate cancer, this study provides valuable clinical implications that favor RP over PDAT for treatment of Asian populations. However, the possibility that survival differences have been overestimated due to not accounting for potential confounding characteristics must be considered. |
| Databáze: | OpenAIRE |
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