Cerebrospinal fluid monoclonal gammopathy in multiple myeloma and Waldenstrom's macroglobulinemia
| Autor: | P. Hansotia, W. Friedenberg, K. Gani |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
biology
business.industry Albumin Antibodies Monoclonal Waldenstrom macroglobulinemia Macroglobulinemia medicine.disease Cerebrospinal fluid Hypergammaglobulinemia Immunoglobulin G Monoclonal Immunology medicine biology.protein Humans Immunohistochemistry Neurology (clinical) Waldenstrom Macroglobulinemia Antibody Multiple Myeloma business Serum Albumin Multiple myeloma |
| Zdroj: | Neurology. 33:1411-1411 |
| ISSN: | 1526-632X 0028-3878 |
| Popis: | Serum ratios of monoclonal immunoglobulin (Ig) to total protein, monoclonal immunoglobulin to albumin, CSF/serum Ig-albumin index, and CSF to serum monoclonal immunoglobulin were obtained in 21 patients with multiple myeloma and 2 with Waldenström's macroglobulinemia. Twelve patients (3 with CNS complications) showed CSF monoclonal proteins similar to their serum. CSF IgA levels above 10 mg/dl, IgG levels above 25 mg/dl, CSF-serum IgG ratios above 0.0034 and CSF-serum IgA ratios above 0.0051 were seen in patients with neurologic complications. Our preliminary data may signal early CNS involvement in multiple myeloma. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|