Reduced clot retraction rate and altered platelet energy production in patients with asthma
| Autor: | Marian Tomasiak, Anna Bodzenta-Lukaszyk, Tomasz Misztal, Tomasz Rusak, M. M. Tomasiak-Lozowska |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Pulmonary and Respiratory Medicine Spirometry Adult Blood Platelets Male medicine.medical_specialty Clot Retraction Clot retraction Nitric Oxide 03 medical and health sciences Young Adult Adrenal Cortex Hormones Internal medicine medicine Immunology and Allergy Humans Platelet Lactic Acid Asthma Aged medicine.diagnostic_test business.industry Thrombosis Middle Aged medicine.disease respiratory tract diseases Pulmonary embolism Respiratory Function Tests Thrombelastography Eosinophils Thromboelastometry 030104 developmental biology Coagulation Anesthesia Case-Control Studies Pediatrics Perinatology and Child Health Cardiology Female business circulatory and respiratory physiology |
| Zdroj: | The Journal of asthma : official journal of the Association for the Care of Asthma. 53(6) |
| ISSN: | 1532-4303 |
| Popis: | Asthma enhances the risk of pulmonary embolism. The mechanism of this phenomenon is unclear.We evaluated the kinetics of clot formation, clot retraction rate (CRR), clot volume at 40 min, the rate of lactate production (a marker of aerobic glycolysis in platelets in contracting clots), blood eosinophil count (EOS), nitric oxide in exhaled breath (FENO), and spirometry (FEV1) in 50 healthy controls and in 81 allergic asthmatics (41 subjects with steroid-naïve asthma and 40 with steroid-treated asthma).Thromboelastometry revealed that only steroid-treated asthmatics had slightly activated coagulation. Compared with healthy controls, whole asthmatics demonstrated (p0.05) reduced CRR, higher clot volume at 40 minutes, higher FENO, decreased FEV1, elevated EOS, and augmented lactate production in retracting clots. Reduced CRR was observed also in the absence of native plasma. In whole study population (asthmatics and healthy controls), CRR positively correlated with spirometry (rS = 0.668, p =0.001) and negatively with FENO (rS = -0.543; p0.001), EOS (rS = -0.367, p0.002), and lactate production (rS = -0.791; p0.001). However, in steroid-treated asthmatics, the CRR did not correlate with FENO and EOS. In all study patients lactate production negatively correlated with FEV1 and positively with FENO.Collectively, this data is consistent with the hypothesis that, in asthmatics, reactive nitrogen species produced in the lungs may reduce platelet contractility (and CRR) through the diminution of platelet energy production. CRR inhibition would predispose asthmatics to pulmonary embolism. |
| Databáze: | OpenAIRE |
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