Aneuploidy in atypical fibroxanthoma: DNA content quantification of 10 cases by image analysis
| Autor: | R.P. Reid, M.E Fallowfield, B.A. Michie |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Pathology
medicine.medical_specialty Skin Neoplasms Histology Histiocytoma Benign Fibrous medicine.diagnostic_test Aneuploidy Atypical fibroxanthoma DNA Neoplasm Dermatology Biology medicine.disease Pathology and Forensic Medicine Flow cytometry Lesion chemistry.chemical_compound Tissue sections chemistry Cytology medicine Humans medicine.symptom Ploidy DNA |
| Zdroj: | Journal of Cutaneous Pathology. 21:404-407 |
| ISSN: | 1600-0560 0303-6987 |
| DOI: | 10.1111/j.1600-0560.1994.tb00280.x |
| Popis: | It has recently been reported that atypical fibroxanthoma (AFX) is a predominantly diploid lesion in contrast to malignant fibrous hystiocytoma (MFH) which is usually aneuploid. To test this hypothesis, DNA content quantification was undertaken on Feulgen-stained cytology and tissue section preparations from 10 cases of AFX by image analysis. The large atypical cells which characterize AFX were aneuploid in each case. Smaller spindle-shaped cells found in this lesion were diploid. The results suggest that AFX is indistinguishable from MFH by DNA content estimation and highlight an advantage of image analysis over flow cytometry. |
| Databáze: | OpenAIRE |
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