MORPHINE INFLUENCE ON ADENYLATE CYCLASE ACTIVITY IN PERIPHERAL BLOOD LYMPHOCYTES OF ALCOHOLIC PATIENTS
| Autor: | I. P. Anokhina, T. P. Nebarakova, S. I. Tronnikov, N. L. Vekshina, N. B. Gamaleya |
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| Rok vydání: | 1991 |
| Předmět: |
Adult
Male medicine.medical_specialty Lymphocyte Adenylate kinase (+)-Naloxone Pharmacology Alcohol Withdrawal Delirium chemistry.chemical_compound Alcohol intoxication Internal medicine medicine Humans Lymphocytes Ethanol Morphine Naloxone business.industry General Medicine medicine.disease Enzyme Activation Alcoholism medicine.anatomical_structure Endocrinology chemistry Toxicity business human activities Cyclase activity Adenylyl Cyclases medicine.drug |
| Zdroj: | Alcohol and Alcoholism. 26:515-518 |
| ISSN: | 1464-3502 0735-0414 |
| DOI: | 10.1093/oxfordjournals.alcalc.a045153 |
| Popis: | The effect of morphine on adenylate cyclase activity in lymphocytes was tested in 20 normal controls, 16 alcoholics in withdrawal and 9 sober alcoholics. Alcoholics in withdrawal were characterized by a significantly increased stimulatory effect of morphine, whereas sober alcoholics showed an inhibitory effect. The morphine effect was abolished by naloxone and correlated with the severity of withdrawal and alcohol intoxication. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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