Corticosterone regulates fear memory via Rac1 activity in the hippocampus
| Autor: | Ze-Yang Ding, Rong-Rong Mao, Qi-Xin Zhou, Cheng Gan, Lin Xu, Ping Gan, Heng Zhou |
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| Rok vydání: | 2016 |
| Předmět: |
Male
rac1 GTP-Binding Protein 0301 basic medicine medicine.medical_specialty Endocrinology Diabetes and Metabolism Hippocampus Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound Receptors Glucocorticoid 0302 clinical medicine Endocrinology Mineralocorticoid receptor Glucocorticoid receptor Downregulation and upregulation Memory Corticosterone Internal medicine medicine Animals Biological Psychiatry Fear processing in the brain Memory Disorders Endocrine and Autonomic Systems Antiglucocorticoid Cognition Fear Rats Psychiatry and Mental health 030104 developmental biology chemistry Psychology Neuroscience Stress Psychological 030217 neurology & neurosurgery |
| Zdroj: | Psychoneuroendocrinology. 71:86-93 |
| ISSN: | 0306-4530 |
| Popis: | Stressful events can generate enduring memories, which may induce certain psychiatric disorders such as post-traumatic stress disorder (PTSD). However, the underlying molecular mechanisms in these processes remain unclear. In this study, we examined whether the active form of the small G protein Rac1, Rac1-GTP, is involved in fear memory. Firstly, we detected the time course changes of Rac1-GTP after foot shocks (a strong stressor) and exogenous corticosterone (CORT) treatment. The data showed that stress and CORT induced the downregulation of Rac1-GTP in the hippocampus. Changes in the serum CORT level were negatively correlated with the level of Rac1-GTP. Additionally, a glucocorticoid receptor antagonist, RU38486, not only recovered the expression of Rac1-GTP but also impaired fear memory. Furthermore, systemic administration of NSC23766, an inhibitor of Rac1-GTP, improved fear memory at 1.5 and 24 h. Therefore, Rac1 activity plays a critical role in stress-related cognition and may be a potential target in stress-related disorders. |
| Databáze: | OpenAIRE |
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