Pathophysiology of Anthrax
| Autor: | Kenneth J. Hendrix, Frederick Klein, David F. Fitzpatrick, William J. Jones, Jerry S. Walker, James P. Dobbs, Bill G. Mahlandt, Ralph E. Lincoln |
|---|---|
| Rok vydání: | 1966 |
| Předmět: |
Spores
Alkalosis In Vitro Techniques Biology Hematocrit Phosphates Anthrax Sepsis Chlorides medicine Animals Cholinesterases Immunology and Allergy Toxins Biological Cholinesterase medicine.diagnostic_test Proteins Nucleated Red Blood Cell Hyperesthesia Hominidae Haplorhini Hypoxia (medical) medicine.disease biology.organism_classification Blood Cell Count Diet Bacillus anthracis Glucose Infectious Diseases Hyperglycemia Immunology biology.protein Calcium Rabbits Blood Gas Analysis medicine.symptom Blood Chemical Analysis |
| Zdroj: | Journal of Infectious Diseases. 116:123-138 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/116.2.123 |
| Popis: | The disease syndromes produced by both Bacillus anthracis organisms and by sterile in vitro toxins are orderly and predictable. Most of the signs and changes in the blood cellular, and gaseous elements occur late in the septicemic phase of disease, whereas similar changes occur earlier after administration of toxins. The only pathophysiological responses peculiar to any of the three species of animals used in this study, the rhesus monkey, chimpanzee, and rabbit, was the presence of nucleated red blood cells in the rabbit and the absence of these cells in the two primates. All effects appear to be nonspecific and include evaluation of white blood count with a marked shift to the lift, decreased Ca2+, Na+, and cholinesterase with increased K-, Cl-, and HPO4(2-). Hyperesthesia frequently was observed, and late in the course of disease a terminal hypoglycemia with alkalosis and hypoxia occurred. One of the most significant observations was failure of the body to respond to the organisms per se but rather to the toxins of B. anthracis. (Author) |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|