Fas and FasL genetic polymorphisms in women with recurrent pregnancy loss: a case-control study

Autor:	Jong Kwan Jun, Ae Ra Han, Sung Ki Lee, Hyeon Jeong Jeong, Kwang Moon Yang, Min A. Hong, Eun Chan Paik, Young Min Choi, Jin Ju Kim
Rok vydání:	2018
Předmět:	0301 basic medicine Abortion Habitual Fas Ligand Protein Genotype chemical and pharmacologic phenomena Single-nucleotide polymorphism Polymorphism Single Nucleotide Fas ligand 03 medical and health sciences 0302 clinical medicine Asian People Pregnancy Republic of Korea Medicine Humans Genetic Predisposition to Disease fas Receptor Complicated pregnancy reproductive and urinary physiology 030219 obstetrics & reproductive medicine business.industry Case-control study Obstetrics and Gynecology hemic and immune systems General Medicine Abnormal expression medicine.disease 030104 developmental biology Reproductive Medicine Apoptosis Case-Control Studies embryonic structures Cancer research Female business
Zdroj:	Human fertility (Cambridge, England). 22(3)
ISSN:	1742-8149
Popis:	Aberrant apoptosis at the trophoblast-maternal interface and abnormal expression of Fas and Fas ligand (FasL) have been reported in complicated pregnancies with recurrent pregnancy losses (RPL) and preeclampsia. We assessed the prevalence of Fas and FasL genetic polymorphisms in Korean women with RPL and in fertile controls. In total, 306 women with RPL and 298 fertile controls were enrolled. Genotype distributions of Fas and FasL in RPL patients versus fertile controls were examined under the Hardy-Weinberg equilibrium. Fas -670 A/G genotype (AA versus AG versus GG
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b87ac849a6bdcb7dbe47bac52d629671 https://pubmed.ncbi.nlm.nih.gov/29781316 Zobrazit plný text záznamu