Monoclonal antibodies identify conserved epitopes on the polyhedrin of Heliothis zea nuclear polyhedrosis virus

Autor:	C.Y. Kawanishi, Yuan-Shen Huang, Ping C. Hu
Rok vydání:	1984
Předmět:	Baculoviridae biology medicine.drug_class viruses fungi Nuclear Polyhedrosis Virus biology.organism_classification Monoclonal antibody Virology Molecular biology Epitope Virus Polyhedrin biology.protein medicine Antibody Clone (B-cell biology)
Zdroj:	Virology. 143(2)
ISSN:	0042-6822
Popis:	Monoclonal antibodies were formed against polyhedrin from the Heliothis zea S nuclear polyhedrosis virus. The cross-reactivity of these antibodies with polyhedrins and granulins of other occluded baculoviruses indicates that group and subgroup epitopes exist. Evidence is presented that multiple copies of one epitope or a series of closely related epitopes exist on the polyhedrin molecule. The monoclonal antibodies, with the exception of one IgM-producing hybridoma clone, were all of the IgG1 isotype. Clones producing antibodies with identical patterns of reactivity with heterologous polyhedrins and/or granulins but exhibiting different affinities for the homologous antigen (HzSNPV polyhedrin) are demonstrated.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b87a31a6f415921ad3d482dfc2be5dcd https://pubmed.ncbi.nlm.nih.gov/18639853 Zobrazit plný text záznamu