Vitamins C and E prevent AZT-induced leukopenia and loss of cellularity in bone marrow. Studies in mice
| Autor: | M L del Olmo, L Gómez-Cambronero, José García-De-La-Asunción, Juan R. Viña, Joaquín Sastre, Federico V. Pallardó |
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| Rok vydání: | 2007 |
| Předmět: |
Male
Myeloid Antioxidant Anti-HIV Agents viruses medicine.medical_treatment Bone Marrow Cells Mice Inbred Strains Ascorbic Acid Pharmacology medicine.disease_cause Biochemistry Antioxidants chemistry.chemical_compound Mice immune system diseases medicine Animals Vitamin E heterocyclic compounds Leukopenia Chemistry virus diseases General Medicine biochemical phenomena metabolism and nutrition Malondialdehyde Antioxidant vitamins Oxidized Glutathione medicine.anatomical_structure Immunology Bone marrow medicine.symptom Zidovudine Oxidative stress |
| Zdroj: | Free radical research. 41(3) |
| ISSN: | 1071-5762 |
| Popis: | A major limitation in the use of AZT for AIDS treatment is the occurrence of side effects, such as leukopenia. The effects of antioxidant vitamins C and E on AZT-induced leukopenia were investigated in mice. Mice were divided into four groups: (1) controls; (2) AZT-treated; (3) treated with AZT plus vitamins C and E; and (4) pre-treated with vitamins and then treated with AZT plus vitamins. Our results demonstrate that AZT causes leukopenia in mice, which was abrogated by administration of vitamins C and E in the pre-treated group. These vitamins prevented the decrease in cellular content induced by AZT in bone marrow and diminished peroxide levels in myeloid precursors in bone marrow. AZT also caused an increase in plasma malondialdehyde and blood oxidized glutathione levels, which was prevented by the administration of antioxidant vitamins. In conclusion, oxidative stress is involved in AZT-induced leukopenia which may be prevented by antioxidant treatment. |
| Databáze: | OpenAIRE |
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